Special Issue "Virus-based Vaccines"

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A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Antivirals & Vaccines".

Deadline for manuscript submissions: closed (30 April 2014)

Special Issue Editors

Guest Editor
Prof. Dr. Polly Roy
Department of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, Room 363b, Keppel Street, London WC1E 7HT, UK
Website: http://www.lshtm.ac.uk/aboutus/people/roy.polly
E-Mail: polly.roy@lshtm.ac.uk
Phone: +44 20 7927 2324
Fax: +44 20 7927 2839
Interests: orbiviruses; rotaviruses; viral vaccines; virus assembly and structure

Guest Editor
Prof. Dr. Charles J. Russell
Infectious Diseases, MS 330, Room I-6309, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA
Website: http://www.stjude.org/stjude/v/index.jsp?vgnextoid=99a310e88ce70110VgnVCM1000001e0215acRCRD&vgnextchannel=01a813c016118010VgnVCM1000000e2015acRCRD
E-Mail: charles.russell@stjude.org
Phone: +901 595 5648
Fax: +901 595 8559
Interests: emerging influenza viruses; paramyxoviruses; influenza viruses; paramyxoviruses

Special Issue Information

Dear Colleagues,

We are planning to publish a special issue of Viruses devoted to current trends in vaccine development for viral diseases.  This issue will cover the diverse technologies that are currently being used for the development of rationally designed vaccines and will highlight both recombinant protein‑based vaccines and the application of genomic (e.g. RG‑based) technologies in vaccine research. Work on both animal and human vaccines will be considered.

In light of your expertise in the vaccine area, I would like to invite you to submit a review article on your subject for this special issue.

Prof. Dr. Polly Roy
Prof. Dr.Charles Russell
Guest Editors

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs).

Published Papers (13 papers)

by  and
Viruses 2014, 6(8), 3159-3180; doi:10.3390/v6083159
Received: 19 May 2014; in revised form: 31 July 2014 / Accepted: 5 August 2014 / Published: 18 August 2014
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by  and
Viruses 2014, 6(8), 3055-3079; doi:10.3390/v6083055
Received: 12 June 2014; in revised form: 28 July 2014 / Accepted: 29 July 2014 / Published: 7 August 2014
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by , , , , , ,  and
Viruses 2014, 6(7), 2735-2761; doi:10.3390/v6072735
Received: 30 April 2014; in revised form: 25 June 2014 / Accepted: 25 June 2014 / Published: 17 July 2014
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by  and
Viruses 2014, 6(7), 2531-2550; doi:10.3390/v6072531
Received: 30 April 2014; in revised form: 18 June 2014 / Accepted: 19 June 2014 / Published: 25 June 2014
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by  and
Viruses 2014, 6(6), 2465-2494; doi:10.3390/v6062465
Received: 27 March 2014; in revised form: 6 June 2014 / Accepted: 13 June 2014 / Published: 23 June 2014
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by , , , , , , , , ,  and
Viruses 2014, 6(6), 2416-2427; doi:10.3390/v6062416
Received: 30 April 2014; in revised form: 10 June 2014 / Accepted: 11 June 2014 / Published: 20 June 2014
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by ,  and
Viruses 2014, 6(6), 2428-2443; doi:10.3390/v6062428
Received: 10 March 2014; in revised form: 18 May 2014 / Accepted: 21 May 2014 / Published: 20 June 2014
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by
Viruses 2014, 6(6), 2392-2415; doi:10.3390/v6062392
Received: 2 April 2014; in revised form: 3 June 2014 / Accepted: 4 June 2014 / Published: 16 June 2014
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by , ,  and
Viruses 2014, 6(6), 2328-2339; doi:10.3390/v6062328
Received: 13 April 2014; in revised form: 25 May 2014 / Accepted: 30 May 2014 / Published: 6 June 2014
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by , ,  and
Viruses 2014, 6(5), 1974-1991; doi:10.3390/v6051974
Received: 24 February 2014; in revised form: 5 April 2014 / Accepted: 22 April 2014 / Published: 29 April 2014
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by  and
Viruses 2014, 6(4), 1672-1700; doi:10.3390/v6041672
Received: 31 January 2014; in revised form: 28 March 2014 / Accepted: 2 April 2014 / Published: 11 April 2014
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by , , , , , , ,  and
Viruses 2014, 6(2), 856-874; doi:10.3390/v6020856
Received: 20 January 2014; in revised form: 7 February 2014 / Accepted: 8 February 2014 / Published: 18 February 2014
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by , , , ,  and
Viruses 2014, 6(2), 371-390; doi:10.3390/v6020371
Received: 3 December 2013; in revised form: 16 January 2014 / Accepted: 17 January 2014 / Published: 24 January 2014
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Article

Title: Application of Reverse Genetics to the Improvement of Existing and Development of New Rotavirus Vaccines
Authors: Aitor Navarri Nieto and John T. Patton
Abstract: Rotaviruses (RV) belong to the Reoviridae family and are the most important cause of severe gastroenteritis in infants and young children. Development of a complete reverse genetics system that allows engineering of any of the rotavirus double-stranded RNA genome segments remains elusive. However, several single-gene replacement systems have been established for rotavirus, and these have been useful for generating reassortant viruses, introducing foreign sequences into the viral genome, and altering the structure and function of viral molecules. The application of single gene and complete reverse genetics technologies has the potential to improve existing and generate more effective rotavirus vaccines by allowing the rational design of new candidate strains of vaccine viruses. This includes the conversion of circulating virulent viruses into attenuated vaccine candidates via mutation of virulence determinants, modification of immunodominant epitopes of vaccine viruses to match more closely locally circulating rotaviruses, and generation of vaccines viruses with superior stability properties that are more amenable to high titer growth in cell culture. Perhaps most importantly, reverse genetic technologies may provide for the generation of a new class of vaccine viruses that, due to their capacity to express foreign proteins, are capable of inducing protection not only again rotavirus but also other enteric pathogens. In this article, we review the state of the art for rotavirus reverse genetics technologies and consider the potential impact of these technologies on the rotavirus vaccine programs.

 

Announced Papers

  1. Mark R. Schleiss; University of Minnesota, USA
  2. Benedikt Kaufer; Institut für Virologie, 14163 Berlin, Germany
  3. Ed Rybicki; MCB Principal Investigator
  4. Steffen Müller; Stony Brook University

Last update: 4 July 2014

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