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Viruses 2014, 6(7), 2531-2550; doi:10.3390/v6072531

RNA Virus Reverse Genetics and Vaccine Design

1
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
2
Children's Healthcare of Atlanta, Atlanta, GA 30322, USA
*
Author to whom correspondence should be addressed.
Received: 30 April 2014 / Revised: 18 June 2014 / Accepted: 19 June 2014 / Published: 25 June 2014
(This article belongs to the Special Issue Virus-based Vaccines)
View Full-Text   |   Download PDF [760 KB, uploaded 12 May 2015]   |  

Abstract

RNA viruses are capable of rapid spread and severe or potentially lethal disease in both animals and humans. The development of reverse genetics systems for manipulation and study of RNA virus genomes has provided platforms for designing and optimizing viral mutants for vaccine development. Here, we review the impact of RNA virus reverse genetics systems on past and current efforts to design effective and safe viral therapeutics and vaccines. View Full-Text
Keywords: RNA virus; reverse genetics; vaccines RNA virus; reverse genetics; vaccines
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Stobart, C.C.; Moore, M.L. RNA Virus Reverse Genetics and Vaccine Design. Viruses 2014, 6, 2531-2550.

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