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Viruses 2014, 6(2), 371-390; doi:10.3390/v6020371

HSV-2 Vaccine: Current Status and Insight into Factors for Developing an Efficient Vaccine

1
The 2nd Clinical Medical College, Wenzhou Medical University, Wenzhou 325025, Zhejiang, China
2
School of International Studies, Wenzhou Medical University, Wenzhou 325025, Zhejiang, China
3
School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325025, Zhejiang, China
*
Author to whom correspondence should be addressed.
Received: 3 December 2013 / Revised: 16 January 2014 / Accepted: 17 January 2014 / Published: 24 January 2014
(This article belongs to the Special Issue Virus-based Vaccines)
View Full-Text   |   Download PDF [1541 KB, uploaded 12 May 2015]   |  

Abstract

Herpes simplex virus type 2 (HSV-2), a globally sexually transmitted virus, and also one of the main causes of genital ulcer diseases, increases susceptibility to HIV-1. Effective vaccines to prevent HSV-2 infection are not yet available, but are currently being developed. To facilitate this process, the latest progress in development of these vaccines is reviewed in this paper. A summary of the most promising HSV-2 vaccines tested in animals in the last five years is presented, including the main factors, and new ideas for developing an effective vaccine from animal experiments and human clinical trials. Experimental results indicate that future HSV-2 vaccines may depend on a strategy that targets mucosal immunity. Furthermore, estradiol, which increases the effectiveness of vaccines, may be considered as an adjuvant. Therefore, this review is expected to provide possible strategies for development of future HSV-2 vaccines. View Full-Text
Keywords: herpes simplex virus 2; vaccine; mucosal immunity; delivery route; adjuvant; sex hormone herpes simplex virus 2; vaccine; mucosal immunity; delivery route; adjuvant; sex hormone
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhu, X.-P.; Muhammad, Z.S.; Wang, J.-G.; Lin, W.; Guo, S.-K.; Zhang, W. HSV-2 Vaccine: Current Status and Insight into Factors for Developing an Efficient Vaccine. Viruses 2014, 6, 371-390.

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