Vaccination against δ-Retroviruses: The Bovine Leukemia Virus Paradigm
AbstractBovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy. View Full-Text
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Gutiérrez, G.; Rodríguez, S.M.; de Brogniez, A.; Gillet, N.; Golime, R.; Burny, A.; Jaworski, J.-P.; Alvarez, I.; Vagnoni, L.; Trono, K.; Willems, L. Vaccination against δ-Retroviruses: The Bovine Leukemia Virus Paradigm. Viruses 2014, 6, 2416-2427.
Gutiérrez G, Rodríguez SM, de Brogniez A, Gillet N, Golime R, Burny A, Jaworski J-P, Alvarez I, Vagnoni L, Trono K, Willems L. Vaccination against δ-Retroviruses: The Bovine Leukemia Virus Paradigm. Viruses. 2014; 6(6):2416-2427.Chicago/Turabian Style
Gutiérrez, Gerónimo; Rodríguez, Sabrina M.; de Brogniez, Alix; Gillet, Nicolas; Golime, Ramarao; Burny, Arsène; Jaworski, Juan-Pablo; Alvarez, Irene; Vagnoni, Lucas; Trono, Karina; Willems, Luc. 2014. "Vaccination against δ-Retroviruses: The Bovine Leukemia Virus Paradigm." Viruses 6, no. 6: 2416-2427.