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Viruses 2014, 6(6), 2416-2427; https://doi.org/10.3390/v6062416

Vaccination against δ-Retroviruses: The Bovine Leukemia Virus Paradigm

1
Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA, C.C. 1712, Castelar, Argentina
2
Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), 4000 Liège, Belgium
These authors contributed equally to this work.
These authors designed and coordinated this study equally.
*
Author to whom correspondence should be addressed.
Received: 30 April 2014 / Revised: 10 June 2014 / Accepted: 11 June 2014 / Published: 20 June 2014
(This article belongs to the Special Issue Virus-based Vaccines)
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Abstract

Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy. View Full-Text
Keywords: BLV; neutralizing antibody; vaccine; mimotope; HTLV-1; attenuated virus BLV; neutralizing antibody; vaccine; mimotope; HTLV-1; attenuated virus
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Gutiérrez, G.; Rodríguez, S.M.; de Brogniez, A.; Gillet, N.; Golime, R.; Burny, A.; Jaworski, J.-P.; Alvarez, I.; Vagnoni, L.; Trono, K.; Willems, L. Vaccination against δ-Retroviruses: The Bovine Leukemia Virus Paradigm. Viruses 2014, 6, 2416-2427.

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