Viruses 2014, 6(4), 1672-1700; doi:10.3390/v6041672
Review

Matrix and Backstage: Cellular Substrates for Viral Vaccines

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Received: 31 January 2014; in revised form: 28 March 2014 / Accepted: 2 April 2014 / Published: 11 April 2014
(This article belongs to the Special Issue Virus-based Vaccines)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Vaccines are complex products that are manufactured in highly dynamic processes. Cellular substrates are one critical component that can have an enormous impact on reactogenicity of the final preparation, level of attenuation of a live virus, yield of infectious units or antigens, and cost per vaccine dose. Such parameters contribute to feasibility and affordability of vaccine programs both in industrialized countries and developing regions. This review summarizes the diversity of cellular substrates for propagation of viral vaccines from primary tissue explants and embryonated chicken eggs to designed continuous cell lines of human and avian origin.
Keywords: vaccine production; host cells; vaccine substrate; continuous cell lines; primary cell culture
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MDPI and ACS Style

Jordan, I.; Sandig, V. Matrix and Backstage: Cellular Substrates for Viral Vaccines. Viruses 2014, 6, 1672-1700.

AMA Style

Jordan I, Sandig V. Matrix and Backstage: Cellular Substrates for Viral Vaccines. Viruses. 2014; 6(4):1672-1700.

Chicago/Turabian Style

Jordan, Ingo; Sandig, Volker. 2014. "Matrix and Backstage: Cellular Substrates for Viral Vaccines." Viruses 6, no. 4: 1672-1700.


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