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Viruses 2014, 6(4), 1672-1700; doi:10.3390/v6041672

Matrix and Backstage: Cellular Substrates for Viral Vaccines

ProBioGen AG, Goethestr. 54, Berlin 13086, Germany
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Author to whom correspondence should be addressed.
Received: 31 January 2014 / Revised: 28 March 2014 / Accepted: 2 April 2014 / Published: 11 April 2014
(This article belongs to the Special Issue Virus-based Vaccines)
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Abstract

Vaccines are complex products that are manufactured in highly dynamic processes. Cellular substrates are one critical component that can have an enormous impact on reactogenicity of the final preparation, level of attenuation of a live virus, yield of infectious units or antigens, and cost per vaccine dose. Such parameters contribute to feasibility and affordability of vaccine programs both in industrialized countries and developing regions. This review summarizes the diversity of cellular substrates for propagation of viral vaccines from primary tissue explants and embryonated chicken eggs to designed continuous cell lines of human and avian origin.
Keywords: vaccine production; host cells; vaccine substrate; continuous cell lines; primary cell culture vaccine production; host cells; vaccine substrate; continuous cell lines; primary cell culture
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Jordan, I.; Sandig, V. Matrix and Backstage: Cellular Substrates for Viral Vaccines. Viruses 2014, 6, 1672-1700.

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