Special Issue "On-Chip Sensors"


A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: 30 April 2015

Special Issue Editor

Guest Editor
Dr. Kwang W. Oh
Associate Professor, Director of SMALL (Sensors and MicroActuators Learning Lab), Department of Electrical Engineering, State University of New York at Buffalo (SUNY-Buffalo), Buffalo, NY 14260, USA
Website: http://SMALL.buffalo.edu
E-Mail: kwangoh@buffalo.edu
Phone: +1 716 645 1025
Interests: BioMEMS; lab-on-a-chip (LOC); microfluidics; droplet-based microfluidics; blood separation; micro PCR; micro SERS; sensors for LOC

Special Issue Information

Dear Colleagues,

The original idea of lab-on-a-chip (LOC) technology involves integrating on-chip sensors with advanced microfluidic technology to build miniaturized devices that can monitor bio/chemical responses in real time (quantitatively), or on/off signals (qualitatively), without a bulky and complex laboratory setup. Such a technique would find broad and numerous applications in genomics, proteomics, point-of-care testing, chemical analysis, drug discovery and environment monitoring.

(1) Ideally, the on-chip sensors are integrated into the LOC devices, which are disposable. For example, CMOS, electrochemical, FET, RF, mechanical and optical sensors have been integrated with the LOC devices for on-chip sensing. The main challenge is not only to enhance the quality of the on-chip sensors but also to fabricate the LOC devices cost-effectively. (2) Alternatively, the sensors can be assembled into the reusable miniaturized hand-held instruments’ side rather than the disposable LOC devices’ side as stand-alone components. For this approach, user-friendly and contamination-free interfacing between the microfluidic devices and the instruments needs to be highlighted, along with compact design of the instruments. Recent examples include a lens-free holographic microscope installed on an existing smart phone camera. (3) Another methodology is to utilize mobile micro/nano particles/cells as a sensing system in microfluidic devices that can be excited and scanned by external optical instruments, such as micro SERS (surface enhanced Raman scattering) and micro SPR (surface plasmon resonance).

In this special issue, we solicit review articles and original research papers addressing technical challenges on developing on-chip sensors for LOC applications. The papers can cover all aspects of on-chip sensors including, but not limited to, recent developments in the following areas: fabrication and application of on-chip sensors; point-of-care sensing; sensor for LOC systems; CMOS sensor; capacitive sensor; electrochemical sensor; FET sensors; RF sensor; on-chip mechanical sensor (e.g., cantilever, QCM, SAW); on-chip optical sensor; lens-free smartphone microscope; micro SERS; micro SPR; cell-based sensors and nanobio sensors. Authors are invited to contact the guest editors prior to submission if they are uncertain whether their work falls within the general scope of this Special Issue.

Dr. Kwang W. Oh
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).


  • sensor
  • on-chip sensor
  • biosensor
  • nanobio sensor
  • microfluidics
  • lab-on-a-chip, integrated sensor
  • point-of-care sensing
  • electrochemical sensor
  • CMOS sensor
  • FET (field effect transistor) sensor
  • capacitive sensor
  • on-chip optical sensor
  • on-chip mechanical sensor
  • micro SERS
  • micro SPR

Published Papers (8 papers)

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Displaying article 1-8
p. 17192-17211
by , ,  and
Sensors 2014, 14(9), 17192-17211; doi:10.3390/s140917192 (registering DOI)
Received: 15 July 2014; in revised form: 25 August 2014 / Accepted: 3 September 2014 / Published: 16 September 2014
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(This article belongs to the Special Issue On-Chip Sensors)
p. 17008-17036
by , , ,  and
Sensors 2014, 14(9), 17008-17036; doi:10.3390/s140917008
Received: 15 July 2014; in revised form: 29 August 2014 / Accepted: 10 September 2014 / Published: 12 September 2014
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(This article belongs to the Special Issue On-Chip Sensors)
p. 16740-16753
by  and
Sensors 2014, 14(9), 16740-16753; doi:10.3390/s140916740
Received: 1 July 2014; in revised form: 26 August 2014 / Accepted: 4 September 2014 / Published: 9 September 2014
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(This article belongs to the Special Issue On-Chip Sensors)
p. 11714-11734
by ,  and
Sensors 2014, 14(7), 11714-11734; doi:10.3390/s140711714
Received: 16 April 2014; in revised form: 20 June 2014 / Accepted: 25 June 2014 / Published: 2 July 2014
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(This article belongs to the Special Issue On-Chip Sensors)
p. 11225-11244
by  and
Sensors 2014, 14(6), 11225-11244; doi:10.3390/s140611225
Received: 9 April 2014; in revised form: 10 June 2014 / Accepted: 19 June 2014 / Published: 24 June 2014
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(This article belongs to the Special Issue On-Chip Sensors)
p. 9505-9521
by , , , , , , ,  and
Sensors 2014, 14(6), 9505-9521; doi:10.3390/s140609505
Received: 20 January 2014; in revised form: 15 May 2014 / Accepted: 22 May 2014 / Published: 28 May 2014
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(This article belongs to the Special Issue On-Chip Sensors)
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p. 7084-7095
by , , , , ,  and
Sensors 2014, 14(4), 7084-7095; doi:10.3390/s140407084
Received: 14 November 2013; in revised form: 31 March 2014 / Accepted: 9 April 2014 / Published: 22 April 2014
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(This article belongs to the Special Issue On-Chip Sensors)
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p. 6952-6964
by , ,  and
Sensors 2014, 14(4), 6952-6964; doi:10.3390/s140406952
Received: 8 February 2014; in revised form: 4 April 2014 / Accepted: 10 April 2014 / Published: 21 April 2014
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Review
History and Trends in CMOS Instrumentation for Electrochemical Biosensors
Andrew Mason
Electrical and Computer Engineering Department, University of Michigan, USA
CMOS instrumentation has played a pivotal role in the development of many new biosensor technologies. In particular, many advances have been made recently in CMOS circuits for electrochemical biosensors. This paper provides an overview of electrochemical sensor concepts from an instrumentation point of view and reviews the CMOS instrumentation circuits that have been reported for electrochemical biosensors. The paper also previews challenges in adapting CMOS instrumentation into integrated microsystems for liquid-environment biosensor applications. Trends in CMOS electrochemical microsystem development are illustrated to identify future directions in the field of biosensors.

Type of Paper: Review
Title: Detection of mite proteases using Lab-on-chip systems
Authors: Poltronieri, P., Cimaglia, F., Hubert, J., Primiceri, E., Maruccio, G.
Affiliation: Institute of Sciences of Food Productions, National Research Council, ISPA-CNR, Via Lecce-Monteroni, 73100 Lecce, Italy
Mites and beetles are often found contaminating stored products, such as dried fruits. These limit the shelf-life of packaged products. The contamination of stored food by arthropods may seriously endanger human health, as they can cause allergies and serve as vectors of fungal allergens and potentially pathogenic bacteria (Hubert et al., 2015). Several classes of major allergens are produced by house-dust or stored-product mites. Six of these allergens are proteases and related hydrolytic enzymes.
We have previously developed a protein chip containing four protease inhibitors with different specificities toward trypsin-like and cathepsin-like proteases. Recombinant KPI-B1 was used as a control on the chip. The specificities of KPIs with different proteases (i.e., toward different serine and cysteine proteases of the same group) allowed for selective and differential binding, so as to detect various mite protease candidate proteins.
In this review, we discuss the potential of Lab-on-chip techniques to be adapted to screen mite proteins in various foods and industry manufacture lines so as to detect and evaluate the level of contamination by mites. Adequate improvement in packaging sheets will be required to protect foods from infiltration by insect. In addition, several different diets favor the spread of pathogens, such as Pseudomonas, Bacillus, and Clostridium spp. Novel detection platforms may be ready for users, thus allowing for less expensive instrumentation to evaluate and detect the interactions by means of fluorescence, impedometry, or other direct methods. Thus, a fast surveillance system based on LOC will support the food industry and consumption.

Last update: 15 September 2014

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