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Sensors 2014, 14(7), 11714-11734; doi:10.3390/s140711714
Review

Cell Patterning for Liver Tissue Engineering via Dielectrophoretic Mechanisms

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1,2,*  and 1,2
Received: 16 April 2014 / Revised: 20 June 2014 / Accepted: 25 June 2014 / Published: 2 July 2014
(This article belongs to the Special Issue On-Chip Sensors)
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Abstract

Liver transplantation is the most common treatment for patients with end-stage liver failure. However, liver transplantation is greatly limited by a shortage of donors. Liver tissue engineering may offer an alternative by providing an implantable engineered liver. Currently, diverse types of engineering approaches for in vitro liver cell culture are available, including scaffold-based methods, microfluidic platforms, and micropatterning techniques. Active cell patterning via dielectrophoretic (DEP) force showed some advantages over other methods, including high speed, ease of handling, high precision and being label-free. This article summarizes liver function and regenerative mechanisms for better understanding in developing engineered liver. We then review recent advances in liver tissue engineering techniques and focus on DEP-based cell patterning, including microelectrode design and patterning configuration.
Keywords: cell patterning; dielectrophoresis; tissue engineering; hepatocytes; liver; artificial organ; artificial liver; engineered liver; lab-on-a-chip; BioMEMS liver cell patterning; dielectrophoresis; tissue engineering; hepatocytes; liver; artificial organ; artificial liver; engineered liver; lab-on-a-chip; BioMEMS liver
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yahya, W.N.W.; Kadri, N.A.; Ibrahim, F. Cell Patterning for Liver Tissue Engineering via Dielectrophoretic Mechanisms. Sensors 2014, 14, 11714-11734.

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