Special Issue "Biochips"

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A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (15 April 2012)

Special Issue Editor

Guest Editor
Prof. Dr. Dietmar Knopp
Institute of Hydrochemistry and Chair for Analytical Chemistry, Group Bioanalytics, Technische Universität München, Marchioninistr. 17, 81377 München, Germany
Website: http://www.ws.chemie.tu-muenchen.de/groups/bioanalytic/people0/knopp/
E-Mail: dietmar.knopp@ch.tum.de
Interests: immunoassays; immunoanalysis; ELISA; CLEIA; immunoaffinity chromatography; automated flow-immunoassay; sol-gel chemistry; dipstick; microarray; immunochips; antibody generation; environmental analysis; food analysis; haptens; polycyclic aromatic hydrocarbons; mycotoxins; pesticides; diclofenac; molecularly imprinted polymers; functionalized nanomaterials

Special Issue Information

Dear Colleagues,

Mainly due to the multiplexing capability enabling in parallel analysis at the same time of up to thousands of different biorecognition events recorded in a miniaturized device, biochip technology revealed a fast-maturating field during the last decades. The analysis platform which benefits from contributions of different disciplines such as material science, synthetic chemistry, chemical biology, and engineering, leads to tremendous cost and time savings and, therefore, offers a multitude of applications, such as in drug discovery, genomics, proteomics, biomarker discovery, food and environment safety, and point-of-care-medical analysis. Depending on single-use /reuse capability, biochips are made from different rigid substrates such as glass, silicon, quartz, or plastic on which biological material is placed for analysis. At the early beginning, most attention was devoted to DNA chips but later applications involve the use of advanced bioactive surfaces which may control or monitor communication at molecular and cellular level with other biological objects such as proteins, polysaccharides, tissues, living cells, and small organic molecules. The basic principle of operation of  a biochip consists of (1) functionalization onto different positions on the chip surface or the channel walls using, e.g., robotic spotting or lithography, (2) biointeraction when the chip is coming into contact with the target compound, (3) readout with an appropriate technique, e.g., an optical scanner, a charge-coupled device (CCD) imager or electrochemically, after all non-bound molecules were removed and, (4) evaluation of the results using special software. There is an increasing interest for label-free detection methods, like atomic force microscopy (AFM), mass spectrometry, and surface plasmon resonance (SPR). Also, the  immobilization procedure is a field in which new methods are developed very frequently, mainly focussed on using covalent and site-specific techniques in order to retain natural conformation and activity of biomolecules and prevent nonspecific binding of sample constituents. Nanotechnology, e.g., nanobeads preparation and arraying techniques and particle lithography, is expected to provide new materials and solutions to enhance biochip characteristics.

Prof. Dr. Dietmar Knopp
Guest Editor

Keywords

  • biochip
  • microchip
  • nanochip
  • biomolecules
  • DNA
  • proteins
  • antibodies
  • microarray
  • microspot array
  • genomics
  • proteomics
  • cell assay
  • tissue array
  • drug discovery
  • diagnostics
  • biomarker
  • point-of-care
  • food safety
  • environment
  • surface plasmon resonance (SPR)
  • atomic force microscopy (AFM)
  • mass spectrometry (MS)
  • multiplexing
  • analytical platform
  • biorecognition
  • miniaturization
  • microfabrication
  • surface functionalization
  • immobilization
  • spotting
  • patterning
  • lithography
  • optical scanner
  • CCD imaging
  • microfluidics
  • lab-on-a-chip
  • immunoassays
  • nanotechnology
  • biosensors
  • immobilized beads

Published Papers (13 papers)

Sensors 2012, 12(11), 15119-15132; doi:10.3390/s121115119
Received: 8 October 2012; in revised form: 18 October 2012 / Accepted: 2 November 2012 / Published: 6 November 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (1291 KB) | HTML Full-text | XML Full-text

Sensors 2012, 12(9), 12710-12728; doi:10.3390/s120912710
Received: 31 August 2012; in revised form: 6 September 2012 / Accepted: 10 September 2012 / Published: 18 September 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (963 KB) | HTML Full-text | XML Full-text

Sensors 2012, 12(8), 11013-11060; doi:10.3390/s120811013
Received: 19 June 2012; in revised form: 10 July 2012 / Accepted: 17 July 2012 / Published: 8 August 2012
Show/Hide Abstract | Cited by 6 | PDF Full-text (971 KB) | HTML Full-text | XML Full-text

Sensors 2012, 12(7), 9530-9550; doi:10.3390/s120709530
Received: 9 May 2012; in revised form: 5 June 2012 / Accepted: 16 June 2012 / Published: 11 July 2012
Show/Hide Abstract | Cited by 8 | PDF Full-text (1044 KB) | HTML Full-text | XML Full-text

Sensors 2012, 12(7), 9234-9252; doi:10.3390/s120709234
Received: 8 June 2012; in revised form: 14 June 2012 / Accepted: 15 June 2012 / Published: 5 July 2012
Show/Hide Abstract | Cited by 4 | PDF Full-text (1202 KB) | HTML Full-text | XML Full-text

Sensors 2012, 12(6), 6967-6977; doi:10.3390/s120606967
Received: 16 April 2012; in revised form: 15 May 2012 / Accepted: 21 May 2012 / Published: 25 May 2012
Show/Hide Abstract | Cited by 4 | PDF Full-text (456 KB) | HTML Full-text | XML Full-text

Sensors 2012, 12(3), 2710-2728; doi:10.3390/s120302710
Received: 6 February 2012; in revised form: 20 February 2012 / Accepted: 27 February 2012 / Published: 29 February 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (427 KB) | HTML Full-text | XML Full-text

Sensors 2012, 12(2), 1494-1508; doi:10.3390/s120201494
Received: 13 December 2011; in revised form: 13 January 2012 / Accepted: 29 January 2012 / Published: 3 February 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (490 KB) | HTML Full-text | XML Full-text

Sensors 2012, 12(2), 1455-1467; doi:10.3390/s120201455
Received: 30 December 2011; in revised form: 19 January 2012 / Accepted: 31 January 2012 / Published: 1 February 2012
Show/Hide Abstract | Cited by 5 | PDF Full-text (2126 KB) | HTML Full-text | XML Full-text | Supplementary Files

Sensors 2011, 11(11), 11021-11035; doi:10.3390/s111111021
Received: 8 October 2011; in revised form: 17 November 2011 / Accepted: 17 November 2011 / Published: 23 November 2011
Show/Hide Abstract | Cited by 9 | PDF Full-text (2036 KB) | HTML Full-text | XML Full-text | Supplementary Files

Sensors 2011, 11(11), 10940-10957; doi:10.3390/s111110940
Received: 24 October 2011; in revised form: 9 November 2011 / Accepted: 18 November 2011 / Published: 22 November 2011
Show/Hide Abstract | PDF Full-text (3834 KB) | HTML Full-text | XML Full-text
abstract graphic

Sensors 2011, 11(11), 10038-10047; doi:10.3390/s111110038
Received: 5 September 2011; in revised form: 5 October 2011 / Accepted: 17 October 2011 / Published: 25 October 2011
Show/Hide Abstract | Cited by 2 | PDF Full-text (626 KB) | HTML Full-text | XML Full-text

Sensors 2011, 11(8), 8018-8027; doi:10.3390/s110808018
Received: 16 June 2011; in revised form: 16 July 2011 / Accepted: 21 July 2011 / Published: 15 August 2011
Show/Hide Abstract | Cited by 3 | PDF Full-text (1195 KB) | HTML Full-text | XML Full-text
abstract graphic

Last update: 4 March 2014

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