Next Article in Journal
Performance Study of the Application of Artificial Neural Networks to the Completion and Prediction of Data Retrieved by Underwater Sensors
Next Article in Special Issue
Miniaturized Protein Microarray with Internal Calibration as Point-of-Care Device for Diagnosis of Neonatal Sepsis
Previous Article in Journal
Accuracy and Resolution of Kinect Depth Data for Indoor Mapping Applications
Previous Article in Special Issue
System-Level Biochip for Impedance Sensing and Programmable Manipulation of Bladder Cancer Cells
Sensors 2012, 12(2), 1455-1467; doi:10.3390/s120201455
Article

An Aluminum Microfluidic Chip Fabrication Using a Convenient Micromilling Process for Fluorescent Poly(DL-lactide-co-glycolide) Microparticle Generation

1,2
, 1
, 3
, 4
, 5,*  and 1
Received: 30 December 2011; in revised form: 19 January 2012 / Accepted: 31 January 2012 / Published: 1 February 2012
(This article belongs to the Special Issue Biochips)
View Full-Text   |   Download PDF [2126 KB, uploaded 21 June 2014]   |   Browse Figures
Abstract: This study presents the development of a robust aluminum-based microfluidic chip fabricated by conventional mechanical micromachining (computer numerical control-based micro-milling process). It applied the aluminum-based microfluidic chip to form poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulating CdSe/ZnS quantum dots (QDs). A cross-flow design and flow-focusing system were employed to control the oil-in-water (o/w) emulsification to ensure the generation of uniformly-sized droplets. The size of the droplets could be tuned by adjusting the flow rates of the water and oil phases. The proposed microfluidic platform is easy to fabricate, set up, organize as well as program, and is valuable for further applications under harsh reaction conditions (high temperature and/or strong organic solvent systems). The proposed method has the advantages of actively controlling the droplet diameter, with a narrow size distribution, good sphericity, as well as being a simple process with a high throughput. In addition to the fluorescent PLGA microparticles in this study, this approach can also be applied to many applications in the pharmaceutical and biomedical area.
Keywords: microfluidic emulsification; poly(lactic-co-glycolic acid) (PLGA); quantum dots (QDs); microsphere microfluidic emulsification; poly(lactic-co-glycolic acid) (PLGA); quantum dots (QDs); microsphere
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Lin, Y.-S.; Yang, C.-H.; Wang, C.-Y.; Chang, F.-R.; Huang, K.-S.; Hsieh, W.-C. An Aluminum Microfluidic Chip Fabrication Using a Convenient Micromilling Process for Fluorescent Poly(DL-lactide-co-glycolide) Microparticle Generation. Sensors 2012, 12, 1455-1467.

AMA Style

Lin Y-S, Yang C-H, Wang C-Y, Chang F-R, Huang K-S, Hsieh W-C. An Aluminum Microfluidic Chip Fabrication Using a Convenient Micromilling Process for Fluorescent Poly(DL-lactide-co-glycolide) Microparticle Generation. Sensors. 2012; 12(2):1455-1467.

Chicago/Turabian Style

Lin, Yung-Sheng; Yang, Chih-Hui; Wang, Chih-Yu; Chang, Fang-Rong; Huang, Keng-Shiang; Hsieh, Wan-Chen. 2012. "An Aluminum Microfluidic Chip Fabrication Using a Convenient Micromilling Process for Fluorescent Poly(DL-lactide-co-glycolide) Microparticle Generation." Sensors 12, no. 2: 1455-1467.


Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert