Special Issue "Cell-penetrating Peptides"

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A special issue of Pharmaceuticals (ISSN 1424-8247).

Deadline for manuscript submissions: closed (30 September 2012)

Special Issue Editor

Guest Editor
Prof. Dr. Vladimir P. Torchilin
Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Mugar Building, Rm 312, 360 Huntington Avenue, Boston, MA 02129, USA
Website: http://www.northeastern.edu/bouve/directory/faculty.php?name=Vladimir%20P.%20Torchilin
E-Mail: v.torchilin@neu.edu
Phone: +617 373 3206
Fax: +617 373 7509
Interests: Drug carriers, Drug delivery sytems, Drug targeting, Liposomes, Micelles, Experimental cancer immunology, Imaging agents

Special Issue Information

Dear Colleagues,

Intracellular delivery of therapeutic molecules is one of the key problems in drug delivery in general. Many pharmaceutical agents should be delivered intracellularly to exert their therapeutic action inside cytoplasm or onto individual organelles, such as nuclei, lysosomes, or mitochondria. However, cell membranes prevent proteins, peptides, and nanoparticulate drug carriers from entering cells. So far, multiple and only partially successful attempts have been made to bring various drugs and drug-loaded pharmaceutical carriers directly into the cell cytoplasm bypassing the endocytic pathway, to protect drugs and DNA from the lysosomal degradation.

A promising approach that seems to be the solution of overcoming the cellular barrier for intracellular drug delivery has emerged over the last decade. In this approach, certain proteins or peptides can be tethered to the hydrophilic drug of interest and together the construct possesses the ability to translocate across the plasma membrane and deliver the payload intracellularly; the process termed as “protein transduction”. Such proteins or peptides contain domains of less than 20 amino acids, Protein Transduction Domains (PTDs) or Cell Penetrating Peptides (CPPs) that are highly rich in basic residues. These peptides have been used for intracellular delivery of various cargoes with molecular weights significantly greater than their own. This special issue will be dealing with pharmaceutical application of cell-penetrating peptides – a challenging and promising area in pharmaceutical research.

Prof. Dr. Vladimir P. Torchilin
Guest Editor

Keywords

  • intracellular delivery
  • cell-penetrating peptides
  • protein transduction domains
  • drug targeting
  • pharmaceutical nanocarriers

Published Papers (23 papers)

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Displaying article 1-23
p. 320-339
by , , , ,  and
Pharmaceuticals 2013, 6(3), 320-339; doi:10.3390/ph6030320
Received: 23 February 2013; in revised form: 6 March 2013 / Accepted: 7 March 2013 / Published: 18 March 2013
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(This article belongs to the Special Issue Cell-penetrating Peptides)
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p. 184-203
by , , , , ,  and
Pharmaceuticals 2013, 6(2), 184-203; doi:10.3390/ph6020184
Received: 1 November 2012; in revised form: 29 January 2013 / Accepted: 30 January 2013 / Published: 6 February 2013
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(This article belongs to the Special Issue Cell-penetrating Peptides)
p. 204-222
by , , , , , ,  and
Pharmaceuticals 2013, 6(2), 204-222; doi:10.3390/ph6020204
Received: 19 November 2012; in revised form: 22 January 2013 / Accepted: 23 January 2013 / Published: 6 February 2013
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(This article belongs to the Special Issue Cell-penetrating Peptides)
p. 32-53
by  and
Pharmaceuticals 2013, 6(1), 32-53; doi:10.3390/ph6010032
Received: 31 October 2012; in revised form: 20 December 2012 / Accepted: 27 December 2012 / Published: 7 January 2013
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(This article belongs to the Special Issue Cell-penetrating Peptides)
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p. 1265-1281
by , , , , ,  and
Pharmaceuticals 2012, 5(12), 1265-1281; doi:10.3390/ph5121265
Received: 10 October 2012; in revised form: 13 November 2012 / Accepted: 14 November 2012 / Published: 23 November 2012
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(This article belongs to the Special Issue Cell-penetrating Peptides)
p. 1177-1209
by , , ,  and
Pharmaceuticals 2012, 5(11), 1177-1209; doi:10.3390/ph5111177
Received: 8 October 2012; in revised form: 25 October 2012 / Accepted: 26 October 2012 / Published: 1 November 2012
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(This article belongs to the Special Issue Cell-penetrating Peptides)
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p. 1092-1102
by , , ,  and
Pharmaceuticals 2012, 5(10), 1092-1102; doi:10.3390/ph5101092
Received: 3 September 2012; in revised form: 27 September 2012 / Accepted: 9 October 2012 / Published: 15 October 2012
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(This article belongs to the Special Issue Cell-penetrating Peptides)
p. 1054-1063
by ,  and
Pharmaceuticals 2012, 5(10), 1054-1063; doi:10.3390/ph5101054
Received: 27 August 2012; in revised form: 21 September 2012 / Accepted: 21 September 2012 / Published: 28 September 2012
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(This article belongs to the Special Issue Cell-penetrating Peptides)
p. 991-1007
by ,  and
Pharmaceuticals 2012, 5(9), 991-1007; doi:10.3390/ph5090991
Received: 21 August 2012; in revised form: 30 August 2012 / Accepted: 6 September 2012 / Published: 12 September 2012
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(This article belongs to the Special Issue Cell-penetrating Peptides)
p. 3594-3613
by , , , , , ,  and
Pharmaceuticals 2010, 3(12), 3594-3613; doi:10.3390/ph3123594
Received: 17 November 2010; Accepted: 1 December 2010 / Published: 15 December 2010
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(This article belongs to the Special Issue Cell-penetrating Peptides)
p. 3435-3460
by , , ,  and
Pharmaceuticals 2010, 3(11), 3435-3460; doi:10.3390/ph3113435
Received: 4 October 2010; in revised form: 23 October 2010 / Accepted: 29 October 2010 / Published: 1 November 2010
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(This article belongs to the Special Issue Cell-penetrating Peptides)
p. 1456-1490
by ,  and
Pharmaceuticals 2010, 3(5), 1456-1490; doi:10.3390/ph3051456
Received: 8 January 2010; in revised form: 29 April 2010 / Accepted: 5 May 2010 / Published: 14 May 2010
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p. 1232-1240
by , ,  and
Pharmaceuticals 2010, 3(4), 1232-1240; doi:10.3390/ph3041232
Received: 11 February 2010; in revised form: 16 April 2010 / Accepted: 21 April 2010 / Published: 23 April 2010
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p. 1093-1107
by , , ,  and
Pharmaceuticals 2010, 3(4), 1093-1107; doi:10.3390/ph3041093
Received: 18 March 2010; Accepted: 11 April 2010 / Published: 13 April 2010
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(This article belongs to the Special Issue Cell-penetrating Peptides)
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p. 961-993
by , ,  and
Pharmaceuticals 2010, 3(4), 961-993; doi:10.3390/ph3040961
Received: 22 December 2009; in revised form: 20 February 2010 / Accepted: 29 March 2010 / Published: 30 March 2010
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(This article belongs to the Special Issue Cell-penetrating Peptides)
p. 1045-1062
by , , ,  and
Pharmaceuticals 2010, 3(4), 1045-1062; doi:10.3390/ph3041045
Received: 22 December 2009; in revised form: 23 March 2010 / Accepted: 29 March 2010 / Published: 30 March 2010
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(This article belongs to the Special Issue Cell-penetrating Peptides)
p. 621-635
by , , ,  and
Pharmaceuticals 2010, 3(3), 621-635; doi:10.3390/ph3030621
Received: 28 December 2009; in revised form: 5 March 2010 / Accepted: 9 March 2010 / Published: 12 March 2010
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(This article belongs to the Special Issue Cell-penetrating Peptides)
p. 636-666
by  and
Pharmaceuticals 2010, 3(3), 636-666; doi:10.3390/ph3030636
Received: 18 December 2010; in revised form: 10 February 2010 / Accepted: 9 March 2010 / Published: 12 March 2010
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p. 600-620
by  and
Pharmaceuticals 2010, 3(3), 600-620; doi:10.3390/ph3030600
Received: 26 December 2009; in revised form: 2 February 2010 / Accepted: 10 March 2010 / Published: 11 March 2010
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(This article belongs to the Special Issue Cell-penetrating Peptides)
p. 448-470
by  and
Pharmaceuticals 2010, 3(3), 448-470; doi:10.3390/ph3030448
Received: 24 December 2009; in revised form: 6 February 2010 / Accepted: 1 March 2010 / Published: 2 March 2010
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(This article belongs to the Special Issue Cell-penetrating Peptides)
p. 379-392
by  and
Pharmaceuticals 2010, 3(2), 379-392; doi:10.3390/ph3020379
Received: 18 December 2008; in revised form: 20 January 2010 / Accepted: 28 January 2010 / Published: 3 February 2010
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(This article belongs to the Special Issue Cell-penetrating Peptides)
p. 110-124
by  and
Pharmaceuticals 2010, 3(1), 110-124; doi:10.3390/ph3010110
Received: 24 October 2009; in revised form: 22 December 2009 / Accepted: 24 December 2009 / Published: 8 January 2010
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p. 49-65
by , , , , ,  and
Pharmaceuticals 2009, 2(2), 49-65; doi:10.3390/ph2020049
Received: 10 August 2009; in revised form: 22 September 2009 / Accepted: 24 September 2009 / Published: 25 September 2009
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Last update: 4 March 2014

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