Next Article in Journal
Hybridoma-Derived Idiotype Vaccine for Lymphoma: Approval Must Wait
Next Article in Special Issue
Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems
Previous Article in Journal / Special Issue
Distribution of CPP-Protein Complexes in Freshly Resected Human Tissue Material
Pharmaceuticals 2010, 3(3), 636-666; doi:10.3390/ph3030636
Review

Dendritic Guanidines as Efficient Analogues of Cell Penetrating Peptides

1 and 1,2,*
Received: 18 December 2010; in revised form: 10 February 2010 / Accepted: 9 March 2010 / Published: 12 March 2010
(This article belongs to the Special Issue Cell-penetrating Peptides)
View Full-Text   |   Download PDF [398 KB, uploaded 12 March 2010]   |   Browse Figures
Abstract: The widespread application of cell penetrating agents to clinical therapeutics and imaging agents relies on the ability to prepare them on a large scale and to readily conjugate them to their cargos. Dendritic analogues of cell penetrating peptides, with multiple guanidine groups on their peripheries offer advantages as their high symmetry allows them to be efficiently synthesized, while orthogonal functionalities at their focal points allow them to be conjugated to cargo using simple synthetic methods. Their chemical structures and properties are also highly tunable as their flexibility and the number of guanidine groups can be tuned by altering the dendritic backbone or the linkages to the guanidine groups. This review describes the development of cell-penetrating dendrimers based on several different backbones, their structure-property relationships, and comparisons of their efficacies with those of known cell penetrating peptides. The toxicities of these dendritic guanidines are also reported as well as their application towards the intracellular delivery of biologically significant cargos including proteins and nanoparticles.
Keywords: cell penetrating peptide; dendrimer; guanidine; drug delivery; cell-uptake; toxicity cell penetrating peptide; dendrimer; guanidine; drug delivery; cell-uptake; toxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Bonduelle, C.V.; Gillies, E.R. Dendritic Guanidines as Efficient Analogues of Cell Penetrating Peptides. Pharmaceuticals 2010, 3, 636-666.

AMA Style

Bonduelle CV, Gillies ER. Dendritic Guanidines as Efficient Analogues of Cell Penetrating Peptides. Pharmaceuticals. 2010; 3(3):636-666.

Chicago/Turabian Style

Bonduelle, Colin V.; Gillies, Elizabeth R. 2010. "Dendritic Guanidines as Efficient Analogues of Cell Penetrating Peptides." Pharmaceuticals 3, no. 3: 636-666.


Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert