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Pharmaceuticals 2010, 3(3), 600-620; doi:10.3390/ph3030600

Targeting the Tumour: Cell Penetrating Peptides for Molecular Imaging and Radiotherapy

Gray Institute for Radiation Oncology and Biology, University of Oxford/Old Road Campus Research Building, Off Roosevelt Drive, Churchill Hospital, Oxford OX3 7DQ, UK
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Received: 26 December 2009 / Revised: 2 February 2010 / Accepted: 10 March 2010 / Published: 11 March 2010
(This article belongs to the Special Issue Cell-penetrating Peptides 2012)
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Abstract

Over the last couple of years, the number of original papers and reviews discussing various applications of cell penetrating peptides (CPPs) has grown exponentially. This is not remarkable since CPPs are capable of transporting the most varying cargo across cell membranes which is one of the biggest problems in drug delivery and targeted therapy. In this review, we focus on the use of CPPs and related peptides for delivery of imaging contrast agents and radionuclides to cells and tissues with the ultimate goal of in vivo molecular imaging and molecular radiotherapy of intracellular and even intranuclear targets. View Full-Text
Keywords: cell penetrating peptides; molecular imaging; radioimmunotherapy cell penetrating peptides; molecular imaging; radioimmunotherapy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kersemans, V.; Cornelissen, B. Targeting the Tumour: Cell Penetrating Peptides for Molecular Imaging and Radiotherapy. Pharmaceuticals 2010, 3, 600-620.

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