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Pharmaceuticals 2010, 3(3), 448-470; doi:10.3390/ph3030448
Review

Cell-Penetrating Peptides for Antiviral Drug Development

 and *
Received: 24 December 2009; in revised form: 6 February 2010 / Accepted: 1 March 2010 / Published: 2 March 2010
(This article belongs to the Special Issue Cell-penetrating Peptides)
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Abstract: Viral diseases affect hundreds of millions of people worldwide, and the few available drugs to treat these diseases often come with limitations. The key obstacle to the development of new antiviral agents is their delivery into infected cells in vivo. Cell-penetrating peptides (CPPs) are short peptides that can cross the cellular lipid bilayer with the remarkable capability to shuttle conjugated cargoes into cells. CPPs have been successfully utilized to enhance the cellular uptake and intracellular trafficking of antiviral molecules, and thereby increase the inhibitory activity of potential antiviral proteins and oligonucleotide analogues, both in cultured cells and in animal models. This review will address the notable findings of these studies, highlighting some promising results and discussing the challenges CPP technology has to overcome for further clinical applications.
Keywords: cell-penetrating peptide; antivirals; antisense; drug delivery cell-penetrating peptide; antivirals; antisense; drug delivery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Delcroix, M.; Riley, L.W. Cell-Penetrating Peptides for Antiviral Drug Development. Pharmaceuticals 2010, 3, 448-470.

AMA Style

Delcroix M, Riley LW. Cell-Penetrating Peptides for Antiviral Drug Development. Pharmaceuticals. 2010; 3(3):448-470.

Chicago/Turabian Style

Delcroix, Melaine; Riley, Lee W. 2010. "Cell-Penetrating Peptides for Antiviral Drug Development." Pharmaceuticals 3, no. 3: 448-470.



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