Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies

doi:10.3390/ph5090991

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Pharmaceuticals 2012, 5(9), 991-1007; doi:10.3390/ph5090991

Review

Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies

Jakob Regberg^1,* , Artita Srimanee^1,2 and Ülo Langel¹

¹ Department of Neurochemistry, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Svante Arrhenius väg 21A, SE-106 91 Stockholm, Sweden ² Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudhya Rd. Bangkok 10400, Thailand

* Author to whom correspondence should be addressed.

Received: 21 August 2012; in revised form: 30 August 2012 / Accepted: 6 September 2012 / Published: 12 September 2012

(This article belongs to the Special Issue Cell-penetrating Peptides)

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Abstract: Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells and thereby increase the efficacy of the treatment, either of conventional small molecular drugs or oligonucleotide based therapeutics. This review is focused on the cancer applications of cell penetrating peptides as delivery systems; different aspects of drug loading, cargoes and delivery are discussed together with methods for targeted delivery, activatable cell-penetrating peptides and transducible agents coupled to cell-penetrating peptides.

Keywords: cell penetrating peptides; cancer; drug delivery; oligonucleotides; siRNA therapeutics; cell targeting peptides

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MDPI and ACS Style

Regberg, J.; Srimanee, A.; Langel, Ü. Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies. Pharmaceuticals 2012, 5, 991-1007.

AMA Style

Regberg J, Srimanee A, Langel Ü. Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies. Pharmaceuticals. 2012; 5(9):991-1007.

Chicago/Turabian Style

Regberg, Jakob; Srimanee, Artita; Langel, Ülo. 2012. "Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies." Pharmaceuticals 5, no. 9: 991-1007.

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