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Pharmaceuticals 2012, 5(9), 991-1007; doi:10.3390/ph5090991
Review

Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies

1,* , 1,2 and 1
Received: 21 August 2012; in revised form: 30 August 2012 / Accepted: 6 September 2012 / Published: 12 September 2012
(This article belongs to the Special Issue Cell-penetrating Peptides)
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Abstract: Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells and thereby increase the efficacy of the treatment, either of conventional small molecular drugs or oligonucleotide based therapeutics. This review is focused on the cancer applications of cell penetrating peptides as delivery systems; different aspects of drug loading, cargoes and delivery are discussed together with methods for targeted delivery, activatable cell-penetrating peptides and transducible agents coupled to cell-penetrating peptides.
Keywords: cell penetrating peptides; cancer; drug delivery; oligonucleotides; siRNA therapeutics; cell targeting peptides cell penetrating peptides; cancer; drug delivery; oligonucleotides; siRNA therapeutics; cell targeting peptides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Regberg, J.; Srimanee, A.; Langel, Ü. Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies. Pharmaceuticals 2012, 5, 991-1007.

AMA Style

Regberg J, Srimanee A, Langel Ü. Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies. Pharmaceuticals. 2012; 5(9):991-1007.

Chicago/Turabian Style

Regberg, Jakob; Srimanee, Artita; Langel, Ülo. 2012. "Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies." Pharmaceuticals 5, no. 9: 991-1007.



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