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Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain
Istituto di Ricerche Farmacologiche \"Mario Negri\", Via La Masa 19, 20157 Milano, Italy
* Author to whom correspondence should be addressed.
Received: 18 December 2008; in revised form: 20 January 2010 / Accepted: 28 January 2010 / Published: 3 February 2010
Abstract: The inability of most drugs to cross the blood-brain barrier and/or plasma membrane limits their use for biomedical applications in the brain. Cell Permeable Peptides (CPPs) overcome this problem and are effective in vivo, crossing the plasma membrane and the blood-brain barrier. CPPs deliver a wide variety of compounds intracellularly in an active form. In fact, many bioactive cargoes have neuroprotective properties, and due to their ability to block protein-protein interactions, offer exciting perspectives in the clinical setting. In this review we give an overview of the Cell Permeable Peptides strategy to deliver neuroprotectants against neurodegeneration in the CNS.
Keywords: CPPs; neuroprotection; protein-protein interaction; drug discovery; brain
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Antoniou, X.; Borsello, T. Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain. Pharmaceuticals 2010, 3, 379-392.
Antoniou X, Borsello T. Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain. Pharmaceuticals. 2010; 3(2):379-392.
Antoniou, Xanthi; Borsello, Tiziana. 2010. "Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain." Pharmaceuticals 3, no. 2: 379-392.