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Pharmaceuticals 2010, 3(2), 379-392; doi:10.3390/ph3020379

Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain

Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, 20157 Milano, Italy
* Author to whom correspondence should be addressed.
Received: 18 December 2008 / Revised: 20 January 2010 / Accepted: 28 January 2010 / Published: 3 February 2010
(This article belongs to the Special Issue Cell-penetrating Peptides 2012)
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The inability of most drugs to cross the blood-brain barrier and/or plasma membrane limits their use for biomedical applications in the brain. Cell Permeable Peptides (CPPs) overcome this problem and are effective in vivo, crossing the plasma membrane and the blood-brain barrier. CPPs deliver a wide variety of compounds intracellularly in an active form. In fact, many bioactive cargoes have neuroprotective properties, and due to their ability to block protein-protein interactions, offer exciting perspectives in the clinical setting. In this review we give an overview of the Cell Permeable Peptides strategy to deliver neuroprotectants against neurodegeneration in the CNS.
Keywords: CPPs; neuroprotection; protein-protein interaction; drug discovery; brain CPPs; neuroprotection; protein-protein interaction; drug discovery; brain
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Antoniou, X.; Borsello, T. Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain. Pharmaceuticals 2010, 3, 379-392.

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