Special Issue "Micellar Drug Delivery"
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (30 November 2012)
Prof. Dr. Vladimir P. Torchilin (Website)
University Distinguished Professor, Director, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, 140 The Fenway, room 214, 360 Huntington Avenue Boston, MA 02115, USA
Fax: +617 373 7509
Interests: drug carriers; drug delivery sytems; drug targeting; liposomes; micelles; experimental cancer immunology; imaging agents
Micells including polymeric micelles represent an important class of pharmaceutical carriers for poorly soluble diagnostic and therapeutic agents. Sable micelles with low CMC values maintain stability upon dilution and in biological fluids, demonstrate prolonged circulation times in vivo, and can be effectively loaded with various poorly soluble pharmaceuticals. Drug-loaded micelles demonstrate an increased accumulation in tumors via the enhanced permeability and retention (EPR) effect, and cytotoxicity of micellar formulations is usually markedly higher compared to free drugs. The potential of micellar drugs may be further improved by attaching targeting ligands, such as specific antibodies, to the micelle surface. By proper modification or synthetic chemistry, the micelles could be made stimuli-sensitive and capable of intracellular penetration. Many of these aspects of micellar drug delivery systems will be considered in this issue.
Prof. Dr. Vladimir P. Torchilin
- pharmaceutical micelles
- polymeric micelles
- lipid-core micelles
- drug delivery
- drug targeting
- poorly soluble drugs
- drug solubilization