Special Issue "Micellar Drug Delivery"
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (30 November 2012)
Prof. Dr. Vladimir P. Torchilin
Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Mugar Building, Rm 312, 360 Huntington Avenue, Boston, MA 02129, USA
Phone: +617 373 3206
Fax: +617 373 7509
Interests: Drug carriers, Drug delivery sytems, Drug targeting, Liposomes, Micelles, Experimental cancer immunology, Imaging agents
Micells including polymeric micelles represent an important class of pharmaceutical carriers for poorly soluble diagnostic and therapeutic agents. Sable micelles with low CMC values maintain stability upon dilution and in biological fluids, demonstrate prolonged circulation times in vivo, and can be effectively loaded with various poorly soluble pharmaceuticals. Drug-loaded micelles demonstrate an increased accumulation in tumors via the enhanced permeability and retention (EPR) effect, and cytotoxicity of micellar formulations is usually markedly higher compared to free drugs. The potential of micellar drugs may be further improved by attaching targeting ligands, such as specific antibodies, to the micelle surface. By proper modification or synthetic chemistry, the micelles could be made stimuli-sensitive and capable of intracellular penetration. Many of these aspects of micellar drug delivery systems will be considered in this issue.
Prof. Dr. Vladimir P. Torchilin
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed Open Access quarterly journal published by MDPI.
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- pharmaceutical micelles
- polymeric micelles
- lipid-core micelles
- drug delivery
- drug targeting
- poorly soluble drugs
- drug solubilization
Pharmaceutics 2013, 5(1), 81-93; doi:10.3390/pharmaceutics5010081
Received: 13 November 2012; in revised form: 20 December 2012 / Accepted: 21 December 2012 / Published: 27 December 2012| Download PDF Full-text (470 KB) | Download XML Full-text
Review: Exploring Polymeric Micelles for Improved Delivery of Anticancer Agents: Recent Developments in Preclinical Studies
Pharmaceutics 2013, 5(1), 201-219; doi:10.3390/pharmaceutics5010201
Received: 21 December 2012; in revised form: 28 February 2013 / Accepted: 13 March 2013 / Published: 22 March 2013| Download PDF Full-text (269 KB) | Download XML Full-text
Pharmaceutics 2013, 5(2), 329-352; doi:10.3390/pharmaceutics5020329
Received: 22 January 2013; in revised form: 9 May 2013 / Accepted: 16 May 2013 / Published: 27 May 2013| Download PDF Full-text (345 KB) | Download XML Full-text
Last update: 7 January 2013