Special Issue "Micellar Drug Delivery"

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A special issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: closed (30 November 2012)

Special Issue Editor

Guest Editor
Prof. Dr. Vladimir P. Torchilin
University Distinguished Professor, Director, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, 140 The Fenway, room 214, 360 Huntington Avenue Boston, MA 02115, USA
Website: http://www.northeastern.edu/bouve/directory/faculty.php?name=Vladimir%20P.%20Torchilin
Fax: +617 373 7509
Interests: drug carriers; drug delivery sytems; drug targeting; liposomes; micelles; experimental cancer immunology; imaging agents

Special Issue Information

Dear Colleagues,

Micells including polymeric micelles represent an important class of pharmaceutical carriers for poorly soluble diagnostic and therapeutic agents. Sable micelles with low CMC values maintain stability upon dilution and in biological fluids, demonstrate prolonged circulation times in vivo, and can be effectively loaded with various poorly soluble pharmaceuticals. Drug-loaded micelles demonstrate an increased accumulation in tumors via the enhanced permeability and retention (EPR) effect, and cytotoxicity of micellar formulations is usually markedly higher compared to free drugs. The potential of micellar drugs may be further improved by attaching targeting ligands, such as specific antibodies, to the micelle surface. By proper modification or synthetic chemistry, the micelles could be made stimuli-sensitive and capable of intracellular penetration. Many of these aspects of micellar drug delivery systems will be considered in this issue.

Prof. Dr. Vladimir P. Torchilin
Guest Editor

Keywords

  • pharmaceutical micelles
  • polymeric micelles
  • lipid-core micelles
  • drug delivery
  • drug targeting
  • poorly soluble drugs
  • drug solubilization

Published Papers (3 papers)

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Displaying article 1-3
p. 329-352
by ,  and
Pharmaceutics 2013, 5(2), 329-352; doi:10.3390/pharmaceutics5020329
Received: 22 January 2013 / Revised: 9 May 2013 / Accepted: 16 May 2013 / Published: 27 May 2013
Show/Hide Abstract | Cited by 17 | PDF Full-text (345 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Micellar Drug Delivery)
p. 201-219
by ,  and
Pharmaceutics 2013, 5(1), 201-219; doi:10.3390/pharmaceutics5010201
Received: 21 December 2012 / Revised: 28 February 2013 / Accepted: 13 March 2013 / Published: 22 March 2013
Show/Hide Abstract | Cited by 8 | PDF Full-text (269 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Micellar Drug Delivery)
p. 81-93
by , , , ,  and
Pharmaceutics 2013, 5(1), 81-93; doi:10.3390/pharmaceutics5010081
Received: 13 November 2012 / Revised: 20 December 2012 / Accepted: 21 December 2012 / Published: 27 December 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (470 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Micellar Drug Delivery)
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Last update: 4 March 2014

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