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Building Cell Selectivity into CPP-Mediated Strategies
Institute for Research in Biomedicine (IRB Barcelona), Barcelona Science Park, Baldiri Reixac 10, Barcelona, Spain
Department of Organic Chemistry, University of Barcelona, Martí i Franquès 1-11, Barcelona, Spain
* Authors to whom correspondence should be addressed.
Received: 8 January 2010; in revised form: 29 April 2010 / Accepted: 5 May 2010 / Published: 14 May 2010
Abstract: There is a pressing need for more effective and selective therapies for cancer and other diseases. Consequently, much effort is being devoted to the development of alternative experimental approaches based on selective systems, which are designed to be specifically directed against target cells. In addition, a large number of highly potent therapeutic molecules are being discovered. However, they do not reach clinical trials because of their low delivery, poor specificity or their incapacity to bypass the plasma membrane. Cell-penetrating peptides (CPPs) are an open door for cell-impermeable compounds to reach intracellular targets. Putting all these together, research is sailing in the direction of the design of systems with the capacity to transport new drugs into a target cell. Some CPPs show cell type specificity while others require modifications or form part of more sophisticated drug delivery systems. In this review article we summarize several strategies for directed drug delivery involving CPPs that have been reported in the literature.
Keywords: cell-penetrating peptides (CPPs); targeted drug delivery; homing peptides; selective targeting; peptide transduction domains (PTDs)
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MDPI and ACS Style
Martín, I.; Teixidó, M.; Giralt, E. Building Cell Selectivity into CPP-Mediated Strategies. Pharmaceuticals 2010, 3, 1456-1490.
Martín I, Teixidó M, Giralt E. Building Cell Selectivity into CPP-Mediated Strategies. Pharmaceuticals. 2010; 3(5):1456-1490.
Martín, Irene; Teixidó, Meritxell; Giralt, Ernest. 2010. "Building Cell Selectivity into CPP-Mediated Strategies." Pharmaceuticals 3, no. 5: 1456-1490.