Special Issue "Plant Polyphenols as Potential Therapeutic Agents for Diabetes and Obesity"
Deadline for manuscript submissions: closed (31 May 2017)
Plant polyphenols are a diverse group of secondary metabolites predominantly synthesised through the shikimic acid and acetate/polyketide pathways. The common perception of polyphenols’ pharmacological effect is that they are mediated through a nonspecific interaction with proteins/enzymes and general antioxidant mechanisms. Numerous specific biological effects at sub-micromolar concentration are however common for many polyphenols. One of the distinct advantages of polyphenols is in their therapeutic potential for complex diseases like diabetes and obesity, where a one drug → one target → one disease approach offers limited efficacy. Through their multifunctional actions, plant polyphenols could ameliorate the various components of such diseases and offer a better outcome through the one drug → multitarget → one/multidisease principle. They could also work in a synergistic manner, with their crude mixtures often showing a higher activity than the isolated pure compounds (multidrug → multitarget → one/multidisease approach). Since both diabetes and obesity cases are now growing in the world with epidemic proportions, our desperate search for safer drugs from natural sources must continue. In this regard, polyphenols are best placed and this Special Issue is designed to scrutinise recent developments in the chemistry, pharmacology, and medical implications of polyphenols as potential therapeutics for diabetes and/or obesity. We are thus inviting colleagues to join us by making their valuable contributions to Molecules.
Prof. Solomon Habtemariam
Prof. Giovanni Lentini
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- plant polyphenols
- mechanism of action
- drug discovery