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Molecules 2017, 22(6), 972; doi:10.3390/molecules22060972

Baccharis trimera (Less.) DC Exhibits an Anti-Adipogenic Effect by Inhibiting the Expression of Proteins Involved in Adipocyte Differentiation

1
Programa de Pós-graduação em Ciencias da Saúde, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte-UFRN, R. Gen. Gustavo Cordeiro de Farias, s/n, Natal-RN 59012-570, Brazil
2
Departamento de Bioquimica, Centro de Biociencias, Universidade Federal do Rio Grande do Norte-UFRN, Av. Salgado Filho 3000, Natal-RN 59078-970, Brazil
3
Instituto Federal de Educação, Ciência a Tecnologia do Rio Grande do Norte (IFRN), Rodovia RN-288, s/n-Nova Caicó, Caicó-RN 59300-000, Brazil
4
Escola Multicampi de Ciências Médicas do Rio Grande do Norte -EMCM/RN, Universidade Federal do Rio Grande do Norte-UFRN, Av. Cel. Martiniano, 354, Caicó-RN 59300-000, Brazil
5
Instituto Federal de Educação, Ciência a Tecnologia do Rio Grande do Norte (IFRN), Rua das margaridas, 300-Conjunto COHAB, Macau-RN 59500-000, Brazil
6
Departamento de Farmácia, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte-UFRN, Rua General Gustavo Cordeiro de Farias, s/n, Natal-RN 59012-570, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Solomon Habtemariam
Received: 17 March 2017 / Revised: 20 May 2017 / Accepted: 7 June 2017 / Published: 12 June 2017
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Abstract

Baccharis trimera (Less.) DC (gorse) is a plant popularly used for the treatment of obesity. In this study, we prepared three B. trimera extracts aqueous extract (AE), decoction (AE-D), and methanol extract (ME) and investigated their antioxidant effects in six different tests and their anti-adipogenic effect in 3T3-L1 cells. The extracts showed a dose-dependent antioxidant activity in all tests. AE was the most potent antioxidant in copper and ferric ion chelation assays, whereas AE-D was the most potent in superoxide and hydroxyl radical scavenging assays, reducing power assay, and total antioxidant capacity analysis. Only ME showed a cytotoxic effect against 3T3-L1 cells. Lipid accumulation decreased in 3T3-L1 adipocytes in the presence of AE and AE-D extracts (0.5 to 1.0 mg/mL). In addition, the extracts dramatically attenuated the levels of adipogenic transcriptional factors, including CCAAT enhancer-binding protein α (C/EBPα), CCAAT enhancer-binding protein β (C/EBPβ), and gamma receptors by peroxisome proliferators (PPARγ), during adipogenesis. AE-D (1.0 mg/mL) caused an approximately 90% reduction in the levels of these molecules. We propose that B. trimera has an anti-adipogenic effect and could be used in the development of functional foods. View Full-Text
Keywords: adipogenesis; antioxidant; chlorogenic acid adipogenesis; antioxidant; chlorogenic acid
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

de Souza Marinho do Nascimento, D.; Oliveira, R.M.; Camara, R.B.G.; Gomes, D.L.; Monte, J.F.S.; Costa, M.S.S.P.; Fernandes, J.M.; Langassner, S.M.Z.; Rocha, H.A.O. Baccharis trimera (Less.) DC Exhibits an Anti-Adipogenic Effect by Inhibiting the Expression of Proteins Involved in Adipocyte Differentiation. Molecules 2017, 22, 972.

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