Next Article in Journal
Production of Laccase by a New Myrothecium verrucaria MD-R-16 Isolated from Pigeon Pea [Cajanus cajan (L.) Millsp.] and its Application on Dye Decolorization
Next Article in Special Issue
Antidiabetic Effects of Tea
Previous Article in Journal
Modified Nucleotides as Substrates of Terminal Deoxynucleotidyl Transferase
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(4), 671; doi:10.3390/molecules22040671

Effects of Flavonoids and Triterpene Analogues from Leaves of Eleutherococcus sieboldianus (Makino) Koidz. ‘Himeukogi’ in 3T3-L1 Preadipocytes

1
College of Science and Technology, Nihon University, 1-5-1 Kandasurugadai, Chiyoda, Tokyo 101-0062, Japan
2
Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
3
Department of Biomedical Information Engineering, Graduate School of Medical Science, Yamagata University, 2-2-2 Iidanishi, Yamagata 990-9585, Japan
4
School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan
5
Department of Pathology and Microbiology ,School of Medicine, Nihon University, 30-1 Ohotaniguchi-kamicho, Itabashi, Tokyo 173-8610, Japan
6
National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Solomon Habtemariam and Giovanni Lentini
Received: 16 February 2017 / Revised: 16 April 2017 / Accepted: 19 April 2017 / Published: 22 April 2017
View Full-Text   |   Download PDF [2486 KB, uploaded 22 April 2017]   |  

Abstract

Eleutherococcus sieboldianus (Makino) Koidz. is a local product from the area in and around Yonezawa City in Yamagata Prefecture, Japan. It has been used as a medicinal plant for a long time. We isolated and identified four types of flavonoid glycosides [astragalin (1), isoquercetin (2), rhamnocitrin 3-O-glucoside (3), and nicotiflorin (4)], a triterpene [methyl hederagenin (5)], and three types of triterpene glycosides [δ-hederin (6), echinocystic acid 3-O-arabinoside (7), and cauloside B (8)] from the methanol extract of E. sieboldianus, which regulates lipid accumulation in 3T3-L1 preadipocytes. Among the compounds isolated, 2 and 8 up- and down-regulated lipid accumulation and insulin induced adipocyte differentiation in 3T3-L1 preadipocytes. Compound 2 induced up-regulation of lipid accumulation and decreased adipocyte size, while 8 down-regulated lipid accumulations without decreasing cell size. Additionally, 2 increased adipogenic proteins [peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein alpha (C/EBPα), and fatty-acid-binding protein 4 (FABP4)]. In contrast, 8 decreased the levels of all adipogenic proteins and glucose transporter type 4 (GLUT4), but increased adiponectin. View Full-Text
Keywords: Eleutherococcus sieboldianus (Makino) Koidz.; adipogenesis; lipolysis; lipogenesis; glucose transporter type 4 Eleutherococcus sieboldianus (Makino) Koidz.; adipogenesis; lipolysis; lipogenesis; glucose transporter type 4
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Nishina, A.; Itagaki, M.; Suzuki, Y.; Koketsu, M.; Ninomiya, M.; Sato, D.; Suzuki, T.; Hayakawa, S.; Kuroda, M.; Kimura, H. Effects of Flavonoids and Triterpene Analogues from Leaves of Eleutherococcus sieboldianus (Makino) Koidz. ‘Himeukogi’ in 3T3-L1 Preadipocytes. Molecules 2017, 22, 671.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top