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Special Issue "Platform Chemical: Hydroxymethylfurfural (HMF)"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".

Deadline for manuscript submissions: closed (30 June 2018)

Special Issue Editors

Guest Editor
Prof. Michela Signoretto

Department of Molecular Sciences and Nano Systems, Università Ca’ Foscari Venezia, and INSTM Consortium, Via Torino 155, 30172 Mestre Venezia, Italy
Website 1 | Website 2 | E-Mail
Interests: development of catalysts and processes for the production of fine chemicals and fuels from biomass; photocatalysts design for fuel production; design of dermo-cosmetic and pharmaceutical formulates; formulation of multifunctional materials for bio-building applications; catalytic production of hydrogen from biomass; development of heterogeneous catalysts and their use in industrial chemistry
Guest Editor
Dr. Federica Menegazzo

Department of Molecular Sciences and Nano Systems, Università Ca’ Foscari Venezia, and INSTM Consortium, Via Torino 155, 30172 Mestre Venezia, Italy
Website 1 | Website 2 | E-Mail
Interests: development of heterogeneous catalysts and processes for biomass valorization; synthesis and characterization of metal nanoparticles; sustainable industrial processes; formulation of materials for green applications; hydrogen production; steam and dry reforming

Special Issue Information

Dear Colleagues,

Biomass conversion to value-added chemicals and fuels over heterogeneous, homogeneous, enzymatic catalysts is one of the goal for the future. 5-hydroxymethyl furfural (HMF) is one of the most important and renewable platform chemicals in the bio-based renaissance. HMF can be obtained from fructose, sucrose, glucose, as well as directly from cellulose, and it can be further transformed into a wide variety of high performance products.

The aim of this Special Issue is to present a current overview of recent developments in the field of the still-open challenges for both HMF production and HMF applications.

All researchers working in the field are cordially invited to contribute original research papers to this Special Issue of Molecules. Reviews are also welcome.

Prof. Dr. Michela Signoretto
Dr. Federica Menegazzo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HMF
  • Biomass valorization
  • biorefinery
  • catalysis
  • renewables
  • lignocellulosic biomasses
  • platform chemicals

Published Papers (2 papers)

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Research

Open AccessArticle Microwave-Assisted Oxalic Acid Pretreatment for the Enhancing of Enzyme Hydrolysis in the Production of Xylose and Arabinose from Bagasse
Molecules 2018, 23(4), 862; https://doi.org/10.3390/molecules23040862
Received: 22 March 2018 / Revised: 31 March 2018 / Accepted: 4 April 2018 / Published: 10 April 2018
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Abstract
In this study, highly-efficient hydrolysis of bagasse into xylose and arabinose sugars (C5 sugars) was developed by microwave-assisted oxalic acid pretreatment under mild reaction conditions. The effects of acid and hydrolysis conditions on the C5 sugar yields were discussed. The results showed that
[...] Read more.
In this study, highly-efficient hydrolysis of bagasse into xylose and arabinose sugars (C5 sugars) was developed by microwave-assisted oxalic acid pretreatment under mild reaction conditions. The effects of acid and hydrolysis conditions on the C5 sugar yields were discussed. The results showed that oxalic acid performed better than hydrochloric acid and maleic acid, and was a promising alternative to sulfuric acid for xylose production at the same acid concentration. The maximum yields of xylose (95.7%) and arabinose (91.5%) were achieved via the microwave-assisted oxalic acid pretreatment (120 °C, 10 min, 0.4 mol/L, solid–liquid ratio of 1:50 g/mL), indicating that almost all xylan-type hemicelluloses were released from the cell wall and hydrolyzed into C5 sugars. After pretreatment, more than 90% of the cellulose in the residual bagasse was converted to glucose (92.2%) by enzymatic hydrolysis. This approach could realize the highly-efficient hydrolysis of xylan from bagasse into C5 sugars, which would enhance the enzyme hydrolysis of treated bagasse into glucose. Full article
(This article belongs to the Special Issue Platform Chemical: Hydroxymethylfurfural (HMF))
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Graphical abstract

Open AccessArticle Facile Chemical Access to Biologically Active Norcantharidin Derivatives from Biomass
Molecules 2017, 22(12), 2210; https://doi.org/10.3390/molecules22122210
Received: 9 November 2017 / Revised: 30 November 2017 / Accepted: 7 December 2017 / Published: 12 December 2017
Cited by 1 | PDF Full-text (821 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Reductive amination of 2,5-diformylfuran (DFF) was used to implement the transition from bio-derived 5-hydroxymethylfurfural (HMF) to pharmaceuticals. The synthesized bis(aminomethyl)furans were utilized as building blocks for the construction of new derivatives with structural cores of naturally occurring biologically active compounds. Using the one-pot
[...] Read more.
Reductive amination of 2,5-diformylfuran (DFF) was used to implement the transition from bio-derived 5-hydroxymethylfurfural (HMF) to pharmaceuticals. The synthesized bis(aminomethyl)furans were utilized as building blocks for the construction of new derivatives with structural cores of naturally occurring biologically active compounds. Using the one-pot procedure, which included the Diels–Alder reaction followed by hydrogenation of the double bond, bio-derived analogues of the anticancer drug norcantharidin were obtained. The cyclization process was diastereoselective, and resulted in the formation of tricyclic products with the endo configuration. Analysis of cytotoxycity for the resulting tricyclic amine-containing compounds showed an increase of anticancer activity as compared with the unsubstituted norcantharimide. Full article
(This article belongs to the Special Issue Platform Chemical: Hydroxymethylfurfural (HMF))
Figures

Graphical abstract

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