Special Issue "Curcumin, Inflammation, and Chronic Diseases: How are They Linked?"
Deadline for manuscript submissions: closed (30 September 2014)
Dr. Sahdeo Prasad
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1901 East Road, Unit 1950 Houston, TX 77054, USA
Interests: Inflammation and cancer; Natural products; Cancer prevention and therapy; Chemosensitization; Inflammatory transcription factors
Chronic infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and high-calorie diet have been recognized as major risk factors for the most chronic diseases, including cancer. All these risk factors are linked to chronic diseases through inflammation. While acute inflammation that persists for the short-term mediates host defense against infections, chronic inflammation that lasts for the long-term can predispose the host to various chronic illnesses, including cancer. Thus, suppression of these proinflammatory pathways may provide opportunities for both the prevention and treatment of chronic diseases. Although traditional medicines have been used for thousands of years, for most such medicines, neither the active component nor their molecular targets have been very well identified. Curcumin, a yellow component of turmeric or curry powder, however, is an exception. Although inhibitors of cyclooxygenase-2 (Celebrex), HER2 (Herceptin), TNF (Enbrel, Humira, Remicade), EGFR (Erbitux and Iressa), Bcr-abl (Gleevec), proteosome (Velcade), and vascular endothelial cell growth factor (Avastin) have been approved for human use by the United States Food and Drug Administration (FDA), curcumin as a single agent can downregulate all these targets. Curcumin can also activate apoptosis, downregulate cell survival gene products, and upregulate p53, p21, and p27. Thus, curcumin regulates multiple targets (multitargeted therapy), which is needed for treatment of most chronic diseases. Also, curcumin is inexpensive and has been found to be safe in human clinical trials. The current Special Issue is devoted to exploring the potential of curcumin in various chronic diseases. The leaders in this field are invited to contribute. Suppression of inflammatory pathways and their role in the prevention and therapy of chronic diseases is the focus of this Special Issue.
Prof. Dr. Bharat B. Aggarwal
Dr. Sahdeo Prasad
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- curcumin chemistry
- molecular targets of curcumin
- curcumin binders
- curcumin analogues
- curcumin and alzheimer
- curcumin and depression
- curcumin and diabetes
- curcumin and cancer prevention and treatment
- curcumin and ckd
- curcumin and aging
- curcumin and obesity