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Molecules 2014, 19(12), 20091-20112; doi:10.3390/molecules191220091

The Chemistry of Curcumin: From Extraction to Therapeutic Agent

Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Mumbai 400085, India
Received: 13 October 2014 / Revised: 25 October 2014 / Accepted: 24 November 2014 / Published: 1 December 2014
(This article belongs to the Special Issue Curcumin, Inflammation, and Chronic Diseases: How are They Linked?)
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Abstract

Curcumin, a pigment from turmeric, is one of the very few promising natural products that has been extensively investigated by researchers from both the biological and chemical point of view. While there are several reviews on the biological and pharmacological effects of curcumin, chemistry reviews are comparatively scarcer. In this article, an overview of different aspects of the unique chemistry research on curcumin will be discussed. These include methods for the extraction from turmeric, laboratory synthesis methods, chemical and photochemical degradation and the chemistry behind its metabolism. Additionally other chemical reactions that have biological relevance like nucleophilic addition reactions, and metal chelation will be discussed. Recent advances in the preparation of new curcumin nanoconjugates with metal and metal oxide nanoparticles will also be mentioned. Directions for future investigations to be undertaken in the chemistry of curcumin have also been suggested. View Full-Text
Keywords: curcumin; extraction; synthesis; degradation; metal chelation; nanoformulation curcumin; extraction; synthesis; degradation; metal chelation; nanoformulation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Priyadarsini, K.I. The Chemistry of Curcumin: From Extraction to Therapeutic Agent. Molecules 2014, 19, 20091-20112.

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