Next Article in Journal
Two New Coumarins from Talaromyces flavus
Next Article in Special Issue
Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments
Previous Article in Journal / Special Issue
Hybrid Curcumin Compounds: A New Strategy for Cancer Treatment
Article Menu

Export Article

Open AccessReview
Molecules 2014, 19(12), 20864-20879; doi:10.3390/molecules191220864

Relevance of the Anti-Inflammatory Properties of Curcumin in Neurodegenerative Diseases and Depression

Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA
*
Author to whom correspondence should be addressed.
Received: 21 October 2014 / Revised: 5 December 2014 / Accepted: 8 December 2014 / Published: 12 December 2014
(This article belongs to the Special Issue Curcumin, Inflammation, and Chronic Diseases: How are They Linked?)
View Full-Text   |   Download PDF [753 KB, uploaded 12 December 2014]   |  

Abstract

This review is an attempt to summarize our current understanding of curcumin’s potential as a neuroprotectant and an antidepressant. This dual property confers a unique advantage to this herbal medication, believed to be devoid of any major side effects, to combat commonly observed co-morbid conditions of a neurodegenerative and a neuropsychiatric disorder. Moreover, in line with the theme of this series, the role of inflammation and stress in these diseases and possible anti-inflammatory effects of curcumin, as well as its interaction with signal transduction proteins as a common denominator in its varied mechanisms of action, are also discussed. Thus, following a brief introduction of curcumin’s pharmacology, we present research suggesting how its anti-inflammatory properties have therapeutic potential in treating a devastating neurological disorder (Parkinson’s disease = PD) and a debilitating neuropsychiatric disorder (major depressive disorder = MDD). It is concluded that curcumin, or better yet, an analog with better and longer bioavailability could be of important therapeutic potential in PD and/or major depression. View Full-Text
Keywords: curcumin; inflammation; depression; Parkinson’s disease; neuroprotection curcumin; inflammation; depression; Parkinson’s disease; neuroprotection
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Tizabi, Y.; Hurley, L.L.; Qualls, Z.; Akinfiresoye, L. Relevance of the Anti-Inflammatory Properties of Curcumin in Neurodegenerative Diseases and Depression. Molecules 2014, 19, 20864-20879.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top