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Special Issue "Plant Derived Natural Products and Age Related Diseases"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: closed (31 January 2018)

Special Issue Editors

Guest Editor
Prof. Dr. Hermann Stuppner

Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Austria
Website | E-Mail
Interests: natural products; pharmacognosy; phytochemistry; analytics; molecular modeling
Guest Editor
Prof. Dr. Leandros A. Skaltsounis

Department of Pharmacognosy and Natural Product Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupoli, Zografou, GR-15771, Athens, Greece
Website | E-Mail
Fax: +302107274594
Interests: natural product chemistry; pharmacognosy

Special Issue Information

Dear Colleagues,

In the absence of overt disease, changes in nutrition and lifestyle are by far the most cost-efficient ways to promote healthy ageing at the population level. Ageing is a complex molecular process driven by diverse molecular pathways that are promoted by both environmental and genetic factors. Numerous studies show that natural compounds represent an amazing inventory of high diversity structural scaffolds that can offer promising candidates in the major healthcare challenge of increasing healthspan and delaying ageing. Especially plant derived compounds (either pure forms or extracts) are involved in several physiological processes and have been shown to possess significant beneficial (chemo-preventive/ delaying cellular senescence or in vivo ageing) effects on human health and to support healthy aging. Plants offer not only products of their primary metabolism, e.g., carbohydrates, proteins or lipids, but also a variety of biologically active secondary natural products (NPs) like polyphenols, essential oils, alkaloids, and many others which exhibit pleiotropic and, likely, therapeutic effects in humans. Today, it is assumed that the generation of NPs has been subjected to natural selection during evolution since the presence of particular secondary metabolite improves the capacity for survival and reproduction of the producing organism. Up to now, approximately 200,000 metabolites have been elucidated in plants and it is expected that the final number will exceed 500,000.

This Special Issue on “Natural Products and Age Related Diseases” will cover several aspects, such as:

  • Medicinal plants used as diet with anti aging effects
  • Plant collection, ethnopharmacology, benefit sharing
  • Pharmacological aspects of aging
  • Key modulators of ageing and age-associated related diseases
  • Mechanism(s) of natural products in prevention of age-related disease
  • Natural products affecting cellular aging signaling
  • Advanced analytical approaches and techniques (microfractionation, microprobe-NMR, LC-SPE-NMR, LC-HR-MSn) and dereplication strategies
  • In vitro and in vivo assays to identify bioactive extracts and NPs with health-span and longevity promoting effects
  • Pharmacokinetics of NPs
  • Gastrointestinal metabolisation of plant derived compounds
  • Aging—computational tools and medicinal chemistry concepts in anti-aging research
Prof. Dr. Hermann Stuppner
Prof. Dr. Leandros A. Skaltsounis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • natural products
  • pharmacology
  • phytochemistry
  • biological effects
  • pharmakinetics
  • plants

Published Papers (2 papers)

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Research

Open AccessArticle Dietary Total Prenylflavonoids from the Fruits of Psoralea corylifolia L. Prevents Age-Related Cognitive Deficits and Down-Regulates Alzheimer’s Markers in SAMP8 Mice
Molecules 2018, 23(1), 196; doi:10.3390/molecules23010196
Received: 2 January 2018 / Revised: 12 January 2018 / Accepted: 17 January 2018 / Published: 18 January 2018
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Abstract
Alzheimer’s disease (AD) is a serious threat for the aging society. In this study, we examined the preventive effect of the total prenylflavonoids (TPFB) prepared from the dried fruits of Psoralea corylifolia L., using an age-related AD mouse model SAMP8. We found that
[...] Read more.
Alzheimer’s disease (AD) is a serious threat for the aging society. In this study, we examined the preventive effect of the total prenylflavonoids (TPFB) prepared from the dried fruits of Psoralea corylifolia L., using an age-related AD mouse model SAMP8. We found that long-term dietary TPFB at 50 mg/kg·day significantly improved cognitive performance of the SAMP8 mice in Morris water maze tests, similar to 150 mg/kg·day of resveratrol, a popular neuro-protective compound. Furthermore, TPFB treatment showed significant improvements in various AD markers in SAMP8 brains, which were restored to near control levels of the normal mice, SAMR1. TPFB significantly reduced the level of amyloid β-peptide 42 (Aβ42), inhibited hyperphosphorylation of the microtubule-associated protein Tau, induced phosphorylation of Ser9 of the glycogen synthase kinase 3β (GSK-3β), and decreased the expression of the proinflammatory cytokines TNFα, IL-6, and IL-1β. Finally, TPFB also markedly reduced the level of serum derivatives of reactive oxygen metabolites (d-ROMs), a biomarker of oxidative stress in vivo. These results showed that dietary TPFB could effectively prevent age-related cognitive deficits and AD-like neurobiochemical changes, and may have a potential role in the prevention of Alzheimer’s disease. Full article
(This article belongs to the Special Issue Plant Derived Natural Products and Age Related Diseases)
Figures

Open AccessArticle Steppogenin Isolated from Cudrania tricuspidata Shows Antineuroinflammatory Effects via NF-κB and MAPK Pathways in LPS-Stimulated BV2 and Primary Rat Microglial Cells
Molecules 2017, 22(12), 2130; doi:10.3390/molecules22122130
Received: 18 October 2017 / Revised: 21 November 2017 / Accepted: 29 November 2017 / Published: 2 December 2017
PDF Full-text (5831 KB) | HTML Full-text | XML Full-text
Abstract
Excessive microglial stimulation has been recognized in several neurodegenerative diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotropic lateral sclerosis (ALS), HIV-associated dementia (HAD), multiple sclerosis (MS), and stroke. When microglia are stimulated, they produce proinflammatory mediators and cytokines, including nitric oxide (NO)
[...] Read more.
Excessive microglial stimulation has been recognized in several neurodegenerative diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotropic lateral sclerosis (ALS), HIV-associated dementia (HAD), multiple sclerosis (MS), and stroke. When microglia are stimulated, they produce proinflammatory mediators and cytokines, including nitric oxide (NO) derived from inducible NO synthase (iNOS), prostaglandin E2 (PGE2) derived from cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-12 (IL-12), and interleukin-6 (IL-6). These inflammatory reactions are related to the nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. Therefore, the modulation of NF-κB and MAPK is vital to prevent microglial activation and confer resistance against neuronal injury. In this study, steppogenin (1) isolated from Cudrania tricuspidata suppressed the neuroinflammatory responses to lipopolysaccharide (LPS). Steppogenin (1) inhibited the production of proinflammatory mediators and cytokines in LPS-challenged BV2 and rat primary microglial cells. Moreover, western blot analysis and immunofluorescence revealed that the nuclear translocation of NF-κB was inhibited in LPS-induced BV2 and rat primary microglial cells. The LPS-stimulated activation of BV2 and rat primary microglial cells was inhibited by steppogenin (1) through the suppression of c-Jun NH2-terminal kinase (JNK) and p38 MAPK signaling. These results suggested that steppogenin (1) exerted antineuroinflammatory effects against acute neuroinflammation in BV2 and rat primary microglial cells by suppressing the activation of NF-κB and MAPK signaling and the production of proinflammatory mediators and cytokines. Full article
(This article belongs to the Special Issue Plant Derived Natural Products and Age Related Diseases)
Figures

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