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Special Issue "Plant Derived Natural Products and Age Related Diseases"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 31 January 2018

Special Issue Editors

Guest Editor
Prof. Dr. Hermann Stuppner

Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Austria
Website | E-Mail
Interests: natural products; pharmacognosy; phytochemistry; analytics; molecular modeling
Guest Editor
Prof. Dr. Leandros A. Skaltsounis

Department of Pharmacognosy and Natural Product Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupoli, Zografou, GR-15771, Athens, Greece
Website | E-Mail
Fax: +302107274594
Interests: natural product chemistry; pharmacognosy

Special Issue Information

Dear Colleagues,

In the absence of overt disease, changes in nutrition and lifestyle are by far the most cost-efficient ways to promote healthy ageing at the population level. Ageing is a complex molecular process driven by diverse molecular pathways that are promoted by both environmental and genetic factors. Numerous studies show that natural compounds represent an amazing inventory of high diversity structural scaffolds that can offer promising candidates in the major healthcare challenge of increasing healthspan and delaying ageing. Especially plant derived compounds (either pure forms or extracts) are involved in several physiological processes and have been shown to possess significant beneficial (chemo-preventive/ delaying cellular senescence or in vivo ageing) effects on human health and to support healthy aging. Plants offer not only products of their primary metabolism, e.g., carbohydrates, proteins or lipids, but also a variety of biologically active secondary natural products (NPs) like polyphenols, essential oils, alkaloids, and many others which exhibit pleiotropic and, likely, therapeutic effects in humans. Today, it is assumed that the generation of NPs has been subjected to natural selection during evolution since the presence of particular secondary metabolite improves the capacity for survival and reproduction of the producing organism. Up to now, approximately 200,000 metabolites have been elucidated in plants and it is expected that the final number will exceed 500,000.

This Special Issue on “Natural Products and Age Related Diseases” will cover several aspects, such as:

  • Medicinal plants used as diet with anti aging effects
  • Plant collection, ethnopharmacology, benefit sharing
  • Pharmacological aspects of aging
  • Key modulators of ageing and age-associated related diseases
  • Mechanism(s) of natural products in prevention of age-related disease
  • Natural products affecting cellular aging signaling
  • Advanced analytical approaches and techniques (microfractionation, microprobe-NMR, LC-SPE-NMR, LC-HR-MSn) and dereplication strategies
  • In vitro and in vivo assays to identify bioactive extracts and NPs with health-span and longevity promoting effects
  • Pharmacokinetics of NPs
  • Gastrointestinal metabolisation of plant derived compounds
  • Aging—computational tools and medicinal chemistry concepts in anti-aging research
Prof. Dr. Hermann Stuppner
Prof. Dr. Leandros A. Skaltsounis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • aging
  • natural products
  • pharmacology
  • phytochemistry
  • biological effects
  • pharmakinetics
  • plants

Published Papers

This special issue is now open for submission.
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