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Molecules 2018, 23(4), 869; https://doi.org/10.3390/molecules23040869

Scutellarin Mitigates Aβ-Induced Neurotoxicity and Improves Behavior Impairments in AD Mice

1
Key Laboratory of Stem Cells and Regenerative Medicine, Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming 650500, China
2
Department of Biochemistry, College of Basic Medicine, Kunming Medical University, Kunming 650500, China
3
School of Pharmacy and Medical Sciences, Sansom Institute, University of South Australia, Adelaide 5001, SA, Australia
*
Authors to whom correspondence should be addressed.
Received: 10 March 2018 / Revised: 2 April 2018 / Accepted: 6 April 2018 / Published: 10 April 2018
(This article belongs to the Special Issue Plant Derived Natural Products and Age Related Diseases)
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Abstract

Alzheimer’s disease (AD) is pathologically characterized by excessive accumulation of amyloid-beta (Aβ) within extracellular spaces of the brain. Aggregation of Aβ has been shown to trigger oxidative stress, inflammation, and neurotoxicity resulting in cognitive dysfunction. In this study, we use models of cerebral Aβ amyloidosis to investigate anti-amyloidogenic effects of scutellarin in vitro and in vivo. Our results show that scutellarin, through binding to Aβ42, efficiently inhibits oligomerization as well as fibril formation and reduces Aβ oligomer-induced neuronal toxicity in cell line SH-SY5Y. After nine months of treatment in APP/PS1 double-transgenic mice, scutellarin significantly improves behavior, reduces soluble and insoluble Aβ levels in the brain and plasma, decreases Aβ plaque associated gliosis and levels of proinflammatory cytokines TNF-α and IL-6, attenuates neuroinflammation, displays anti-amyloidogenic effects, and highlights the beneficial effects of intervention on development or progression of AD-like neuropathology. View Full-Text
Keywords: Alzheimer’s disease (AD); scutellarin; Aβ-amyloid neurotoxicity; APP/PS1 transgenic mice Alzheimer’s disease (AD); scutellarin; Aβ-amyloid neurotoxicity; APP/PS1 transgenic mice
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Zeng, Y.-Q.; Cui, Y.-B.; Gu, J.-H.; Liang, C.; Zhou, X.-F. Scutellarin Mitigates Aβ-Induced Neurotoxicity and Improves Behavior Impairments in AD Mice. Molecules 2018, 23, 869.

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