The theme of this special issue is Healing Materials that focuses on the design, characterization, and implementation of biomaterials for therapeutic applications. Currently, the vast majority of biomaterials employed in modern surgery are designed to passively reside in the tissue, with little to no design considerations for tissue interactions, such as common high performance metals (e.g. stainless steel, titanium alloy, cobalt chromium alloy) and polymers (e.g. polyethylene, silicone rubber, polyurethane). The limited exceptions to this general rule are surface-textured or hydroxyapatite coated materials to encourage tissue in-growth, and degradable polymers such as PLGA. This special issue places emphasis on next generation biomaterials that incorporate coating, molecular immobilization, drug release, matrix degradation or structural strategies that actively influence the healing state of the surrounding tissue.