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Characterization and Biocompatibility of Biopolyester Nanofibers
Department of Materials Chemistry, Faculty of Science and Engineering, Ryukoku University / 1-5 Yokotani, Seta Oe-cho, Otsu-shi, Shiga 520-2194, Japan
Bioengineering Laboratory, RIKEN Institute/Hirosawa 2-1, Wako-shi, Saitama 351-0198, Japan
Universiti Sains Malaysia/11800 Penang, Malaysia
Department of Biomedical Engineering, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita-shi, Osaka 565-8565, Japan
Department of Biomaterial Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo/1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
* Author to whom correspondence should be addressed.
Received: 7 August 2009; in revised form: 17 August 2009 / Accepted: 21 September 2009 / Published: 9 October 2009
Abstract: Biodegradable nanofibers are expected to be promising scaffold materials for biomedical engineering, however, biomedical applications require control of the degradation behavior and tissue response of nanofiber scaffolds in vivo. For this purpose, electrospun nanofibers of poly(hydroxyalkanoate)s (PHAs) and poly(lactide)s (PLAs) were subjected to degradation tests in vitro and in vivo. In this review, characterization and biocompatibility of nanofibers derived from PHAs and PLAs are described. In particular, the effects of the crystalline structure of poly[(R)-3-hydroxybutyrate], stereocomplex structure of PLA, and monomer composition of PHA on the degradation behaviors are described in detail. These studies show the potential of biodegradable polyester nanofibers as scaffold material, for which suitable degradation rate and regulated interaction with surrounding tissues are required.
Keywords: poly(hydroxyalkanoate); poly(lactide); nanofibers; biocompatibility
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Ishii, D.; Ying, T.H.; Yamaoka, T.; Iwata, T. Characterization and Biocompatibility of Biopolyester Nanofibers. Materials 2009, 2, 1520-1546.
Ishii D, Ying TH, Yamaoka T, Iwata T. Characterization and Biocompatibility of Biopolyester Nanofibers. Materials. 2009; 2(4):1520-1546.
Ishii, Daisuke; Ying, Tang H.; Yamaoka, Tetsuji; Iwata, Tadahisa. 2009. "Characterization and Biocompatibility of Biopolyester Nanofibers." Materials 2, no. 4: 1520-1546.