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Materials 2009, 2(4), 1520-1546; doi:10.3390/ma2041520
Review

Characterization and Biocompatibility of Biopolyester Nanofibers

1
, 2,3
, 4
 and 2,5,*
1 Department of Materials Chemistry, Faculty of Science and Engineering, Ryukoku University / 1-5 Yokotani, Seta Oe-cho, Otsu-shi, Shiga 520-2194, Japan 2 Bioengineering Laboratory, RIKEN Institute/Hirosawa 2-1, Wako-shi, Saitama 351-0198, Japan 3 Universiti Sains Malaysia/11800 Penang, Malaysia 4 Department of Biomedical Engineering, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita-shi, Osaka 565-8565, Japan 5 Department of Biomaterial Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo/1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
* Author to whom correspondence should be addressed.
Received: 7 August 2009 / Revised: 17 August 2009 / Accepted: 21 September 2009 / Published: 9 October 2009
(This article belongs to the Special Issue Biocompatibility of Materials)
Download PDF [10569 KB, uploaded 9 October 2009]

Abstract

Biodegradable nanofibers are expected to be promising scaffold materials for biomedical engineering, however, biomedical applications require control of the degradation behavior and tissue response of nanofiber scaffolds in vivo. For this purpose, electrospun nanofibers of poly(hydroxyalkanoate)s (PHAs) and poly(lactide)s (PLAs) were subjected to degradation tests in vitro and in vivo. In this review, characterization and biocompatibility of nanofibers derived from PHAs and PLAs are described. In particular, the effects of the crystalline structure of poly[(R)-3-hydroxybutyrate], stereocomplex structure of PLA, and monomer composition of PHA on the degradation behaviors are described in detail. These studies show the potential of biodegradable polyester nanofibers as scaffold material, for which suitable degradation rate and regulated interaction with surrounding tissues are required.
Keywords: poly(hydroxyalkanoate); poly(lactide); nanofibers; biocompatibility poly(hydroxyalkanoate); poly(lactide); nanofibers; biocompatibility
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ishii, D.; Ying, T.H.; Yamaoka, T.; Iwata, T. Characterization and Biocompatibility of Biopolyester Nanofibers. Materials 2009, 2, 1520-1546.

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