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Materials 2009, 2(2), 613-635; doi:10.3390/ma2020613

Applications and Degradation of Proteins Used as Tissue Engineering Materials

Biomedical Engineering, School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Author to whom correspondence should be addressed.
Received: 7 February 2009 / Revised: 21 April 2009 / Accepted: 22 May 2009 / Published: 26 May 2009
(This article belongs to the Special Issue Biocompatibility of Materials)
View Full-Text   |   Download PDF [158 KB, uploaded 26 May 2009]


This article provides an up-to-date review on the applications of natural polymers, i.e., proteins, as materials for tissue engineering. Proteins are one of the important candidates for tissue engineering materials based on their superior biocompatibility, biodegradation, bioresorbability, and so on. However, their inferior mechanical properties limit their broad application. Currently-available proteins for application in tissue engineering or drug delivery systems, such as fibrin, collagen, zein, silk fibroin, keratin, casein and albumin, and the biodegradation of tissue-engineered substitutes based on proteins are presented. Techniques of scaffold fabrication are also mentioned. Problems and future possibilities for development of protein-based tissue-engineered substitutes are also introduced in this review.
Keywords: proteins; tissue engineering; biodegradation proteins; tissue engineering; biodegradation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, H.-J.; Di, L.; Ren, Q.-S.; Wang, J.-Y. Applications and Degradation of Proteins Used as Tissue Engineering Materials. Materials 2009, 2, 613-635.

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