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Materials 2009, 2(3), 945-957; doi:10.3390/ma2030945

Biocompatibility of Collagen Membranes Assessed by Culturing Human J111 Macrophage Cells

Received: 29 June 2009 / Revised: 4 August 2009 / Accepted: 14 August 2009 / Published: 18 August 2009
(This article belongs to the Special Issue Biocompatibility of Materials)
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We have carried out an in vitro study on the interactions of human macrophages (J111 cell line) with different scaffolds made of type I and II collagen, isolated from horse tendon and from horse articular and trachea cartilage, in order to assess growth properties and biocompatibility of these membranes. We have therefore evaluated cell adhesion and proliferation as well as cytokine production considered an indicator of macrophage activation. The inflammatory response is in fact one of the major causes of collagen destruction thus interfering with cell and tissue behaviour. Moreover, the morphology of cells, seeded on membranes selected for the best characteristics, was described. Results might be relevant for in vivo application such ad “tissue engineering” and/or specialized cells implants.
Keywords: collagen membrane; cell culture; proliferation; cytokine production collagen membrane; cell culture; proliferation; cytokine production
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Aruta, C.G.; Croce, M.A.; Quaglino, D.; Guerra, D.; Tiozzo, R. Biocompatibility of Collagen Membranes Assessed by Culturing Human J111 Macrophage Cells. Materials 2009, 2, 945-957.

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