Special Issue "The Chondrocyte Phenotype in Cartilage Biology"
Deadline for manuscript submissions: closed (31 July 2013)
Dr. Ali Mobasheri
Arthritis Research UK Centre for Sport, Exercise, and Osteoarthritis, Arthritis Research UK Pain Centre, Medical Research Council-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Faculty of Medicine and Health Sciences, The University of Nottingham, UK
Phone: +44 115 9516449
Fax: +44 115 9516440
Interests: quantitative immunohistochemical and immunomorhological techniques; post-genomic techniques including tissue microarray technology and proteomics in veterinary medicine
Articular cartilage is an avascular load-bearing connective tissue with a very limited capacity for intrinsic repair. As a consequence, it is highly prone to structural degradation, making it particularly difficult to restore once it is damaged or lost. The chondrocyte is the only cell type that resides within articular cartilage and is solely responsible for the synthesis and turnover of the extracellular matrix (ECM). For more than two decades chondrocytes have been used clinically in cell-based cartilage repair strategies. However, in most cases dedifferentiated cells are used in procedures such as autologous chondrocyte implantation (ACI). Cell based repair strategies require large numbers of undifferentiated cells. This special issue is entitled "The Chondrocyte Phenotype in Cartilage Biology". It is dedicated to recent progress in our understanding of the unique chondrocyte phenotype and how it can be manipulated for ensuring successful cell-based cartilage repair strategies.
Dr. Ali Mobasheri
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- articular cartilage
- cell culture
- cell-based repair
- autologous chondrocyte implantation
Article: Post-Traumatic Caspase-3 Expression in the Adjacent Areas of Growth Plate Injury Site: A Morphological Study
Int. J. Mol. Sci. 2013, 14(8), 15767-15784; doi:10.3390/ijms140815767
Received: 4 March 2013; in revised form: 3 July 2013 / Accepted: 19 July 2013 / Published: 29 July 2013| Download PDF Full-text (2145 KB) | Download XML Full-text
Article: Comparative Analysis of Osteogenic/Chondrogenic Differentiation Potential in Primary Limb Bud-Derived and C3H10T1/2 Cell Line-Based Mouse Micromass Cultures
Int. J. Mol. Sci. 2013, 14(8), 16141-16167; doi:10.3390/ijms140816141
Received: 17 June 2013; in revised form: 3 July 2013 / Accepted: 4 July 2013 / Published: 5 August 2013| Download PDF Full-text (1399 KB) | Download XML Full-text | Supplementary Files
Article: Increased Chondrocyte Apoptosis Is Associated with Progression of Osteoarthritis in Spontaneous Guinea Pig Models of the Disease
Int. J. Mol. Sci. 2013, 14(9), 17729-17743; doi:10.3390/ijms140917729
Received: 20 June 2013; in revised form: 25 July 2013 / Accepted: 8 August 2013 / Published: 29 August 2013| Download PDF Full-text (1136 KB) | Download XML Full-text
Article: The COX-2 Selective Blocker Etodolac Inhibits TNFα-Induced Apoptosis in Isolated Rabbit Articular Chondrocytes
Int. J. Mol. Sci. 2013, 14(10), 19705-19715; doi:10.3390/ijms141019705
Received: 31 July 2013; in revised form: 6 September 2013 / Accepted: 10 September 2013 / Published: 30 September 2013| Download PDF Full-text (589 KB) | Download XML Full-text
Review: Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis
Int. J. Mol. Sci. 2013, 14(10), 19805-19830; doi:10.3390/ijms141019805
Received: 30 August 2013; in revised form: 17 September 2013 / Accepted: 23 September 2013 / Published: 30 September 2013| Download PDF Full-text (492 KB) | Download XML Full-text
Article: Molecular Study of a Hoxa2 Gain-of-Function in Chondrogenesis: A Model of Idiopathic Proportionate Short Stature
Int. J. Mol. Sci. 2013, 14(10), 20386-20398; doi:10.3390/ijms141020386
Received: 13 June 2013; in revised form: 16 September 2013 / Accepted: 16 September 2013 / Published: 14 October 2013| Download PDF Full-text (2239 KB) | Download XML Full-text | Supplementary Files
Int. J. Mol. Sci. 2013, 14(10), 20793-20808; doi:10.3390/ijms141020793
Received: 23 August 2013; in revised form: 8 October 2013 / Accepted: 8 October 2013 / Published: 16 October 2013| Download PDF Full-text (822 KB) | Download XML Full-text
Int. J. Mol. Sci. 2013, 14(11), 23063-23085; doi:10.3390/ijms141123063
Received: 16 August 2013; in revised form: 30 October 2013 / Accepted: 1 November 2013 / Published: 21 November 2013| Download PDF Full-text (403 KB)
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Review
Title: Redifferentiation of Dedifferentiated Articular Chondrocytes: Effects of Physical and Biochemical Factors in Biomimetic Culture Systems
Author: Ali Mobasheri
Affiliation: Division of Veterinary Medicine, School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, University of Nottingham, Sutton Bonington Campus, College Road, Sutton Bonington, Leicestershire, LE12 5RD, UK; E-Mail: firstname.lastname@example.org
Abstract: Chondrocytes rapidly dedifferentiate after isolation from articular cartilage and cultivation in 2-dimensional culture. The dedifferentiation of chondrocytes makes cell-based treatments for articular cartilage repair a major challenge. Autologous chondrocyte implantation (ACI) is a commonly used cell-based cartilage repair method that relies on the availability of expanded (de-differentiated) chondrocytes. However, the expansion process causes a number of phenotypic changes, requiring re-establishment of the native chondrogenic phenotype to sustain effective repair. Recent studies suggest that 3-dimensional cultures exhibit the most potent chondrogenic potential on dedifferentiated chondrocytes. This paper reviews the recent literature on effects of physical and biochemical factors on chondrocyte redifferentiation.
Last update: 31 August 2012