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Lipid Transport and Metabolism in Healthy and Osteoarthritic Cartilage
Osteoarticular Pathology Laboratory, IIS Fundación Jiménez Díaz, Madrid 28040, Spain
Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
* Author to whom correspondence should be addressed.
Received: 23 August 2013; in revised form: 8 October 2013 / Accepted: 8 October 2013 / Published: 16 October 2013
Abstract: Cartilage is an avascular tissue and cartilage metabolism depends on molecule diffusion from synovial fluid and subchondral bone. Thus, nutrient availability is limited by matrix permeability according to the size and charge of the molecules. Matrix composition limits the access of molecules to chondrocytes, determining cell metabolism and cartilage maintenance. Lipids are important nutrients in chondrocyte metabolism and are available for these cells through de novo synthesis but also through diffusion from surrounding tissues. Cartilage status and osteoarthritis development depend on lipid availability. This paper reviews lipid transport and metabolism in cartilage. We also analyze signalling pathways directly mediated by lipids and those that involve mTOR pathways, both in normal and osteoarthritic cartilage.
Keywords: chondrocyte; cartilage; osteoarthritis; lipid; cholesterol; nutrition
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Villalvilla, A.; Gómez, R.; Largo, R.; Herrero-Beaumont, G. Lipid Transport and Metabolism in Healthy and Osteoarthritic Cartilage. Int. J. Mol. Sci. 2013, 14, 20793-20808.
Villalvilla A, Gómez R, Largo R, Herrero-Beaumont G. Lipid Transport and Metabolism in Healthy and Osteoarthritic Cartilage. International Journal of Molecular Sciences. 2013; 14(10):20793-20808.
Villalvilla, Amanda; Gómez, Rodolfo; Largo, Raquel; Herrero-Beaumont, Gabriel. 2013. "Lipid Transport and Metabolism in Healthy and Osteoarthritic Cartilage." Int. J. Mol. Sci. 14, no. 10: 20793-20808.