Special Issue "Molecular Signaling and Nanobiotechnology: Prospects for Future Antimicrobial Therapy"
Deadline for manuscript submissions: 28 February 2018
Dr. Alexandru Mihai Grumezescu
Department of Science and Engineereing of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, RO-011061, Bucharest, Romania
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Interests: synthesis and characterization of nanobiomaterials; pharmaceutical nanotechnology; drug targeting; drug delivery; anti-biofilm surfaces; nanomodified surfaces; thin films; natural products
Dr. Alina Maria Holban
Microbiology Immunology Department, Faculty of Biology, University of Bucharest, Aleea Portocalelor no 1-3, 060101 Bucharest, Romania
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Interests: in vitro and in vivo bioevaluation of nanostructures; microbiology; immunology; molecular biology; alternative methods for modulating virulence; communication and behavior of microbial pathogens
Since current antimicrobial approaches are becoming less efficient and the antibiotic resistance phenomenon is emerging, alternative therapies are highly investigated for infection control. Recent progress made in order to limit the development of severe infections show that the modulation of certain bacterial behaviors by using signaling molecules or nanosized structures may reduce pathogenicity and virulence, resulting in mild infections. These small molecules proved their efficiency both in vitro and in vivo studies and are currently considered for the development of alternative and ecological anti-infectious therapies, being mostly represented by natural factors obtained from microbial, plant and even animal cells. Nanotechnology, the science of nanometer sized materials, plays a very important role in the implementation of novel antimicrobial therapies by stabilizing, improving the delivery and efficiency and by reducing side effects of many antimicrobial compounds. Moreover, many nanosized materials proved their antimicrobial efficiency in severe and difficult to treat infections, such as those caused by highly resistant pathogens and biofilm associated infectious diseases. The purpose of this special issue is to reveal the most recent and applicative progress developed on the field of novel antimicrobial approaches by highlighting the impact of signaling molecules and nanostructured biomaterials in the design of future anti-infectious therapies.
Dr. Alexandru Mihai Grumezescu
Dr. Alina Maria Holban
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- signaling molecules
- antimicrobial nanoparticles
- anti-biofilm nanocoatings
- molecular communication
- virulence modulation
- natural antibiotics
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Nanoscale technologies for characterizing and evaluating antimicrobial lipids towards therapeutic applications Authors: Bo Kyeong Yoon, Joshua A. Jackman, Elba R. Valle-González, Nam-Joon Cho
Title: Nanoparticles for Signaling in Biodiagnostic and Treatment of Infectious Diseases Authors: Clara Isabel Colino, Carmen Gutierrez Millán, José M. Lanao Abstract: Advances in nanoparticle based systems for the diagnostic and treatment of infectious diseases constitute a promising area of research with important implications in bacterial infections especially in the fight against multidrug resistant strains and bacterial biofilms. In addition nanosystems may be useful for the diagnostic and treatment of viral infections such as HIV or hepatitis, in the treatment of fungal infections or as vaccines. Different commercial test based on nanosystems using biochemical, immunological, bioluminescence procedures are currently available for detecting pathogenic agents. Methodologies based on gold or silver nanoparticles, glass nanospheres or quantum dots among others, have been developed to detect specific agents or to distinguish between gram-positive and gram-negative microorganisms. As an example, in the fight against tuberculosis a magnetophoretic immunoassay based on gold nanoparticles incorporating specific antibodies allows the detection of the Mycobacterium tuberculosis growth. Besides, surface modified silver nanoparticles modulate the antimicrobial macrophage immune responses to Mycobacterium tuberculosis. Also biosensors with virus-specific antibodies have been developed for the detection of viruses. Effective detection of biomarkers such as inmunoglobulins (IgE or IgM) with iron oxide nanoparticles has potential application in the detection of infectious diseases and other pathologies. Nanoparticles functionalized with specific molecules such as proteins, antibodies or DNA may modulate pharmacokinetics and targeting recognition and increase the efficacy of antiinfective drugs. Quorum sensing is a stimuli-response chemical communication process correlated with the population density, that bacteria uses to regulate biofilm formation. Disabling of quorum sensing is an emerging approach for combating its pathogenicity. Natural or synthetic quorum sensing inhibitors may act as anti biofilm agents and be useful to treat multi-drug resistance bacteria. Nanostructured materials interfering with the signal molecules involved in the biofilm growth have been developed for the control of biofilms associated infections. Quorum sensing inhibitors based on chitosan/cyclodextrin/pentasodium tripolyphosphate nanoparticles loaded with Quercetin against Escherichia coli, silver nanoparticles to interrupt Pseudomonas aeruginosa quorum sensing systems or silicon-dioxide nanoparticles among others have been recently developed. Nanoparticles may also modulate or interfere the signaling of TLR4, a mammalian receptor of bacterial endotoxins, involved in the induction of immunity and inflammation.