Special Issue "Neuroprotection against Ischemic Brain Injury"

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A special issue of Brain Sciences (ISSN 2076-3425).

Deadline for manuscript submissions: closed (31 December 2012)

Special Issue Editor

Guest Editor
Dr. Bruno Meloni
Australian Neuromuscular Research Institute (ANRI), The University of Western Australia (M518), 35 Stirling Highway, CRAWLEY WA 6009, Australia
Website: https://www.socrates.uwa.edu.au/Staff/StaffProfile.aspx?Person=BrunoMeloni
E-Mail: bruno.meloni@anri.uwa.edu.au
Phone: +61 9346 3535
Fax: +61 9346 3487
Interests: neuroprotection; stroke and rat stroke models; hypothermia; sodium calcium exchanger; neuroprotective proteins/peptides; adenoviral vectors and magneisum

Special Issue Information

Dear Colleagues,

Ischemic brain injury is a principal pathology in survivors of ischemic stroke and cardiac arrest, two of the most significant diseases of the developed world. At present, acute treatment options to minimise ischemic brain injury are limited. For ischaemic stroke, tPA thrombolysis to restore cerebral blood flow is considered the best available treatment. However, due to tPA’s narrow therapeutic window (3–4.5 h), its use is restricted.

Presently, only moderate hypothermia (33 °C; 12–24 h) has neuroprotective efficacy based on improvements in neurological outcomes following cardiac arrest. Current ongoing phase 3 trials will soon determine if mild-moderate hypothermia (33–35 °C; 24 h) will improve outcome in stroke. Despite these promising interventions there is still an urgent need to develop neuroprotective agents that can be given to a wider patient population and/or can boost the effectiveness of currently available treatments.

The purpose of this special issue is to compile a number of selected articles that provide an overview of pre-clinical and clinical neuroprotective interventions that are currently being investigated or used.

Dr. Bruno Meloni
Guest Editor

Keywords

  • stroke
  • cardiac arrest
  • cerebral ischemia
  • neuroprotection
  • tPA
  • thrombolysis
  • hypothermia
  • blood brain barrier
  • neurovascular unit
  • neuroprotective proteins/peptides
  • combination therapy

Published Papers (19 papers)

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Displaying article 1-19
p. 1415-1416
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Brain Sci. 2013, 3(3), 1415-1416; doi:10.3390/brainsci3031415
Received: 20 August 2013; Accepted: 20 August 2013 / Published: 24 September 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 1395-1414
by  and
Brain Sci. 2013, 3(3), 1395-1414; doi:10.3390/brainsci3031395
Received: 16 July 2013; in revised form: 10 August 2013 / Accepted: 14 August 2013 / Published: 23 September 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 1325-1356
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Brain Sci. 2013, 3(3), 1325-1356; doi:10.3390/brainsci3031325
Received: 23 June 2013; in revised form: 30 July 2013 / Accepted: 14 August 2013 / Published: 5 September 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
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p. 1095-1108
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Brain Sci. 2013, 3(3), 1095-1108; doi:10.3390/brainsci3031095
Received: 5 May 2013; in revised form: 18 June 2013 / Accepted: 27 June 2013 / Published: 22 July 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 1043-1059
by , ,  and
Brain Sci. 2013, 3(3), 1043-1059; doi:10.3390/brainsci3031043
Received: 16 April 2013; in revised form: 14 May 2013 / Accepted: 26 June 2013 / Published: 10 July 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 1013-1022
by , ,  and
Brain Sci. 2013, 3(3), 1013-1022; doi:10.3390/brainsci3031013
Received: 17 May 2013; in revised form: 2 June 2013 / Accepted: 7 June 2013 / Published: 25 June 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 877-907
by ,  and
Brain Sci. 2013, 3(2), 877-907; doi:10.3390/brainsci3020877
Received: 15 February 2013; in revised form: 14 May 2013 / Accepted: 17 May 2013 / Published: 3 June 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 599-614
by ,  and
Brain Sci. 2013, 3(2), 599-614; doi:10.3390/brainsci3020599
Received: 31 January 2013; in revised form: 12 April 2013 / Accepted: 12 April 2013 / Published: 23 April 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 561-598
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Brain Sci. 2013, 3(2), 561-598; doi:10.3390/brainsci3020561
Received: 31 January 2013; in revised form: 14 March 2013 / Accepted: 20 March 2013 / Published: 22 April 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 540-560
by , ,  and
Brain Sci. 2013, 3(2), 540-560; doi:10.3390/brainsci3020540
Received: 8 March 2013; in revised form: 8 April 2013 / Accepted: 9 April 2013 / Published: 19 April 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 521-539
by , , , , , , , ,  and
Brain Sci. 2013, 3(2), 521-539; doi:10.3390/brainsci3020521
Received: 14 February 2013; in revised form: 26 March 2013 / Accepted: 28 March 2013 / Published: 12 April 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 460-503
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Brain Sci. 2013, 3(2), 460-503; doi:10.3390/brainsci3020460
Received: 15 January 2013; in revised form: 23 March 2013 / Accepted: 26 March 2013 / Published: 8 April 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 360-395
by , , , , , ,  and
Brain Sci. 2013, 3(1), 360-395; doi:10.3390/brainsci3010360
Received: 28 December 2012; in revised form: 19 February 2013 / Accepted: 6 March 2013 / Published: 20 March 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 344-359
by ,  and
Brain Sci. 2013, 3(1), 344-359; doi:10.3390/brainsci3010344
Received: 10 December 2012; in revised form: 19 February 2013 / Accepted: 7 March 2013 / Published: 19 March 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 239-261
by , , , ,  and
Brain Sci. 2013, 3(1), 239-261; doi:10.3390/brainsci3010239
Received: 7 December 2012; in revised form: 22 February 2013 / Accepted: 26 February 2013 / Published: 7 March 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 215-238
by , , , , , , , ,  and
Brain Sci. 2013, 3(1), 215-238; doi:10.3390/brainsci3010215
Received: 6 January 2013; in revised form: 21 February 2013 / Accepted: 22 February 2013 / Published: 7 March 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 177-190
by , ,  and
Brain Sci. 2013, 3(1), 177-190; doi:10.3390/brainsci3010177
Received: 22 December 2012; in revised form: 16 February 2013 / Accepted: 21 February 2013 / Published: 5 March 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 191-214
by , ,  and
Brain Sci. 2013, 3(1), 191-214; doi:10.3390/brainsci3010191
Received: 7 January 2013; in revised form: 13 February 2013 / Accepted: 22 February 2013 / Published: 5 March 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
p. 123-142
by  and
Brain Sci. 2013, 3(1), 123-142; doi:10.3390/brainsci3010123
Received: 5 January 2013; in revised form: 23 January 2013 / Accepted: 23 January 2013 / Published: 30 January 2013
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(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
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Last update: 25 February 2014

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