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Brain Sci. 2013, 3(1), 239-261; doi:10.3390/brainsci3010239

Stem Cell Transplantation for Neuroprotection in Stroke

Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA
Author to whom correspondence should be addressed.
Received: 7 December 2012 / Revised: 22 February 2013 / Accepted: 26 February 2013 / Published: 7 March 2013
(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
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Stem cell-based therapies for stroke have expanded substantially over the last decade. The diversity of embryonic and adult tissue sources provides researchers with the ability to harvest an ample supply of stem cells. However, the optimal conditions of stem cell use are still being determined. Along this line of the need for optimization studies, we discuss studies that demonstrate effective dose, timing, and route of stem cells. We recognize that stem cell derivations also provide uniquely individual difficulties and limitations in their therapeutic applications. This review will outline the current knowledge, including benefits and challenges, of the many current sources of stem cells for stroke therapy.
Keywords: stem cells; stroke; cerebral ischemia; transplantation stem cells; stroke; cerebral ischemia; transplantation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Shinozuka, K.; Dailey, T.; Tajiri, N.; Ishikawa, H.; Kaneko, Y.; Borlongan, C.V. Stem Cell Transplantation for Neuroprotection in Stroke. Brain Sci. 2013, 3, 239-261.

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