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The Role of Substance P in Ischaemic Brain Injury
Adelaide Centre for Neuroscience Research, School of Medical Sciences, The University of Adelaide, Adelaide 5005, Australia
* Author to whom correspondence should be addressed.
Received: 5 January 2013; in revised form: 23 January 2013 / Accepted: 23 January 2013 / Published: 30 January 2013
Abstract: Stroke is a leading cause of death, disability and dementia worldwide. Despite extensive pre-clinical investigation, few therapeutic treatment options are available to patients, meaning that death, severe disability and the requirement for long-term rehabilitation are common outcomes. Cell loss and tissue injury following stroke occurs through a number of diverse secondary injury pathways, whose delayed nature provides an opportunity for pharmacological intervention. Amongst these secondary injury factors, increased blood-brain barrier permeability and cerebral oedema are well-documented complications of cerebral ischaemia, whose severity has been shown to be associated with final outcome. Whilst the mechanisms of increased blood-brain barrier permeability and cerebral oedema are largely unknown, recent evidence suggests that the neuropeptide substance P (SP) plays a central role. The aim of this review is to examine the role of SP in ischaemic stroke and report on the potential utility of NK1 tachykinin receptor antagonists as therapeutic agents.
Keywords: substance P; neuropeptides; neurogenic inflammation; cerebral oedema; stroke; tachykinin; blood-brain barrier; cerebral ischaemia
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MDPI and ACS Style
Turner, R.J.; Vink, R. The Role of Substance P in Ischaemic Brain Injury. Brain Sci. 2013, 3, 123-142.
Turner RJ, Vink R. The Role of Substance P in Ischaemic Brain Injury. Brain Sciences. 2013; 3(1):123-142.
Turner, Renée J.; Vink, Robert. 2013. "The Role of Substance P in Ischaemic Brain Injury." Brain Sci. 3, no. 1: 123-142.