Genetic Deletion of Prostacyclin IP Receptor Exacerbates Transient Global Cerebral Ischemia in Aging Mice
Abstract
:1. Introduction
2. Results
2.1. No Change in Cerebral Blood Flow after Global Cerebral Ischemia in Young and Aged WT and IP KO Mice
2.2. Cognitive Deficiency and Motor Dysfunction Induced by Global Cerebral Ischemia Were Enhanced in Young and Aged IP KO Mice
2.3. Genetic Deletion of IP Receptor Enhanced Hippocampal CA1 Neuronal Cell Loss in Young and Aged IP KO Mice
2.4. Genetic Deletion of IP Receptor Exacerbated Microglia Activation and Neutrophil Infiltration in Young and Aged IP KO Mice
2.5. PGI2 IP Receptor Regulates CREB Phosphorylation after Global Cerebral Ischemia
3. Discussion
4. Experimental Section
4.1. Experimental Animals
4.2. Experimental Groups
4.3. Induction of Global Cerebral Ischemia: BCCAO
4.4. T-Maze Spontaneous Alternation
4.5. Open Field Test
4.6. Immunohistochemistry and Quantification
4.7. Statistical Analysis
5. Conclusions
Acknowledgements
Conflict of Interest
References
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Shakil, H.; Saleem, S. Genetic Deletion of Prostacyclin IP Receptor Exacerbates Transient Global Cerebral Ischemia in Aging Mice. Brain Sci. 2013, 3, 1095-1108. https://doi.org/10.3390/brainsci3031095
Shakil H, Saleem S. Genetic Deletion of Prostacyclin IP Receptor Exacerbates Transient Global Cerebral Ischemia in Aging Mice. Brain Sciences. 2013; 3(3):1095-1108. https://doi.org/10.3390/brainsci3031095
Chicago/Turabian StyleShakil, Hania, and Sofiyan Saleem. 2013. "Genetic Deletion of Prostacyclin IP Receptor Exacerbates Transient Global Cerebral Ischemia in Aging Mice" Brain Sciences 3, no. 3: 1095-1108. https://doi.org/10.3390/brainsci3031095