Next Article in Journal
Ethanol Modulates Spontaneous Calcium Waves in Axonal Growth Cones in Vitro
Next Article in Special Issue
Neuroprotective Mechanisms of Taurine against Ischemic Stroke
Previous Article in Journal / Special Issue
NADPH Oxidase as a Therapeutic Target for Neuroprotection against Ischaemic Stroke: Future Perspectives
Brain Sci. 2013, 3(2), 599-614; doi:10.3390/brainsci3020599
Review

Neural Repair and Neuroprotection with Stem Cells in Ischemic Stroke

1,2,3
, 2,3
 and 2,3,*
1 Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA 2 Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA 3 Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
* Author to whom correspondence should be addressed.
Received: 31 January 2013 / Revised: 12 April 2013 / Accepted: 12 April 2013 / Published: 23 April 2013
(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
View Full-Text   |   Download PDF [198 KB, uploaded 23 April 2013]

Abstract

Stem cells have been touted as a potential source of cells for repair in regenerative medicine. When transplanted into the central nervous system, stem cells have been shown to differentiate into neurons and glia. Recent studies, however, have also revealed neuroprotective properties of stem cells. These studies suggest that various types of stem cells are able to protect against the loss of neurons in conditions of ischemic brain injury. In this article, we discuss the use of stem cells for ischemic stroke and the parameters under which neuroprotection can occur in the translation of stem cell therapy to the clinical setting.
Keywords: ischemia; ischemic brain injury; neuroprotection; stem cells; stroke ischemia; ischemic brain injury; neuroprotection; stem cells; stroke
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Stone, L.L.; Grande, A.; Low, W.C. Neural Repair and Neuroprotection with Stem Cells in Ischemic Stroke. Brain Sci. 2013, 3, 599-614.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert