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Brain Sci. 2013, 3(2), 599-614; doi:10.3390/brainsci3020599

Neural Repair and Neuroprotection with Stem Cells in Ischemic Stroke

1
Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
2
Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
3
Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
*
Author to whom correspondence should be addressed.
Received: 31 January 2013 / Revised: 12 April 2013 / Accepted: 12 April 2013 / Published: 23 April 2013
(This article belongs to the Special Issue Neuroprotection against Ischemic Brain Injury)
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Abstract

Stem cells have been touted as a potential source of cells for repair in regenerative medicine. When transplanted into the central nervous system, stem cells have been shown to differentiate into neurons and glia. Recent studies, however, have also revealed neuroprotective properties of stem cells. These studies suggest that various types of stem cells are able to protect against the loss of neurons in conditions of ischemic brain injury. In this article, we discuss the use of stem cells for ischemic stroke and the parameters under which neuroprotection can occur in the translation of stem cell therapy to the clinical setting.
Keywords: ischemia; ischemic brain injury; neuroprotection; stem cells; stroke ischemia; ischemic brain injury; neuroprotection; stem cells; stroke
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Stone, L.L.; Grande, A.; Low, W.C. Neural Repair and Neuroprotection with Stem Cells in Ischemic Stroke. Brain Sci. 2013, 3, 599-614.

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