Table of Contents
Metabolites, Volume 7, Issue 2 (June 2017)
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Cover Story (view full-size image) The tumour suppressor p53 is well-known for its role in cell cycle regulation and DNA damage [...] Read more. The tumour suppressor p53 is well-known for its role in cell cycle regulation and DNA damage repair. It has now emerged that p53 is also an important regulator of cellular metabolism. Many metabolic targets of p53 counteract the specific metabolic alterations found in cancer cells to prevent the Warburg effect. In this review, we summarise recent findings on the metabolic targets of p53 in cancer cells and discuss their roles in tumour development and progression. We also examine how loss of p53 can mitigate the metabolic reprogramming of cancer cells. View the paper here.