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Metabolites 2017, 7(2), 29; doi:10.3390/metabo7020029

Magnetic Resonance Spectroscopy for Detection of 2-Hydroxyglutarate as a Biomarker for IDH Mutation in Gliomas

1
Centre for Pre-clinical Imaging, Department of Cellular and Molecular Physiology, University of Liverpool, Liverpool L69 3BX, UK
2
Institute of Translational Medicine, University of Liverpool, Clinical Science Centre, Lower Lane, Liverpool L9 7LJ, UK
3
Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Lower Lane, Liverpool L9 7LJ, UK
4
Department of Neuroradiology, The Walton Centre NHS Foundation Trust, Lower Lane, Liverpool L9 7LJ, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Madhu Basetti
Received: 12 April 2017 / Revised: 12 June 2017 / Accepted: 12 June 2017 / Published: 19 June 2017
(This article belongs to the Special Issue Cancer Metabolism)
View Full-Text   |   Download PDF [2395 KB, uploaded 19 June 2017]   |  

Abstract

Mutations in the isocitrate dehydrogenase (IDH)1/2 genes are highly prevalent in gliomas and have been suggested to play an important role in the development and progression of the disease. Tumours harbouring these mutations exhibit a significant alteration in their metabolism resulting in the aberrant accumulation of the oncometabolite 2-hydroxygluarate (2-HG). As well as being suggested to play an important role in tumour progression, 2-HG may serve as a surrogate indicator of IDH status through non-invasive detection using magnetic resonance spectroscopy (MRS). In this review, we describe the recent efforts in developing MRS methods for detection and quantification of 2-HG in vivo and provide an assessment of the role of the 2-HG in gliomagenesis and patient prognosis. View Full-Text
Keywords: isocitrate dehydrogenase; glioma; glioblastoma; 2-hydroxyglutarate; magnetic resonance spectroscopy isocitrate dehydrogenase; glioma; glioblastoma; 2-hydroxyglutarate; magnetic resonance spectroscopy
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MDPI and ACS Style

Leather, T.; Jenkinson, M.D.; Das, K.; Poptani, H. Magnetic Resonance Spectroscopy for Detection of 2-Hydroxyglutarate as a Biomarker for IDH Mutation in Gliomas. Metabolites 2017, 7, 29.

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