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Journals
Metabolites
Special Issues
Selected Papers from 1st International Electronic Conference on Metabolomics
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Selected Papers from 1st International Electronic Conference on Metabolomics

A special issue of Metabolites (ISSN 2218-1989).

Deadline for manuscript submissions: closed (30 April 2017)

Special Issue Editors

Prof. Dr. Daniel Raftery

E-Mail Website
Guest Editor
Department of Anesthesiology and Pain Medicine, Northwest Metabolomics Research Center, University of Washington, Seattle, WA, USA
Interests: metabolite profiling; metabolite method development; disease diagnostics; systems biology; NMR spectroscopy; mass spectrometry
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. James Cox

E-Mail Website
Guest Editor
Metabolomics, Proteomics and Mass Spectrometry Cores, University of Utah, Salt Lake City, UT 84112, USA
Interests: yeast metabolism; iron and copper metabolism; metabolomics core; secondary metabolism in antibiotic producing bacteria
Dr. Katja Dettmer-Wilde

E-Mail Website
Guest Editor
Institute of Functional Genomics, University of Regensburg, Am BioPark 9, 93053 Regensburg, Germany
Interests: metabolomics; small molecule analysis; separation science; hyphenated mass spectrometry; sample preparation for metabolomics; cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Adrian S. Culf

E-Mail
Guest Editor
Sussex Research Laboratories, Inc., 100, Sussex Drive, Ottawa, ON K1A OR6, Canada
Interests: small molecule structure determination; NMR; separation science

Special Issue Information

Dear Colleagues,

This Special Issue will collect some selected, invited and contributed talks during the 1st International Electronic Conference on Metabolomics (IECM-1) which was supported by the Metabolites journal, website http://sciforum.net/conference/iecm-1.

Prof. Dr. Daniel Raftery
Prof. Dr. Daniel Raftery
Prof. Dr. James Cox
Dr. Katja Dettmer
Dr. Adrian S. Culf
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Published Papers (1 paper)

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Review
Metabolic Investigations of the Molecular Mechanisms Associated with Parkinson’s Disease
by Robert Powers, Shulei Lei, Annadurai Anandhan, Darrell D. Marshall, Bradley Worley, Ronald L. Cerny, Eric D. Dodds, Yuting Huang, Mihalis I. Panayiotidis, Aglaia Pappa and Rodrigo Franco
Metabolites 2017, 7(2), 22; https://doi.org/10.3390/metabo7020022 - 24 May 2017
Cited by 41 | Viewed by 7421
Abstract
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by fibrillar cytoplasmic aggregates of α-synuclein (i.e., Lewy bodies) and the associated loss of dopaminergic cells in the substantia nigra. Mutations in genes such as α-synuclein (SNCA) account for only 10% of PD [...] Read more.
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by fibrillar cytoplasmic aggregates of α-synuclein (i.e., Lewy bodies) and the associated loss of dopaminergic cells in the substantia nigra. Mutations in genes such as α-synuclein (SNCA) account for only 10% of PD occurrences. Exposure to environmental toxicants including pesticides and metals (e.g., paraquat (PQ) and manganese (Mn)) is also recognized as an important PD risk factor. Thus, aging, genetic alterations, and environmental factors all contribute to the etiology of PD. In fact, both genetic and environmental factors are thought to interact in the promotion of idiopathic PD, but the mechanisms involved are still unclear. In this study, we summarize our findings to date regarding the toxic synergistic effect between α-synuclein and paraquat treatment. We identified an essential role for central carbon (glucose) metabolism in dopaminergic cell death induced by paraquat treatment that is enhanced by the overexpression of α-synuclein. PQ “hijacks” the pentose phosphate pathway (PPP) to increase NADPH reducing equivalents and stimulate paraquat redox cycling, oxidative stress, and cell death. PQ also stimulated an increase in glucose uptake, the translocation of glucose transporters to the plasma membrane, and AMP-activated protein kinase (AMPK) activation. The overexpression of α-synuclein further stimulated an increase in glucose uptake and AMPK activity, but impaired glucose metabolism, likely directing additional carbon to the PPP to supply paraquat redox cycling. Full article
(This article belongs to the Special Issue Selected Papers from 1st International Electronic Conference on Metabolomics)
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