Special Issue "Redox Active Natural Products and Their Interaction with Cellular Signalling Pathways"
Deadline for manuscript submissions: closed (31 May 2014)
Prof. Dr. Claus Jacob
Division of Bioorganic Chemistry, School of Pharmacy, University of Saarland, Campus, 66123 Saarbrücken, Germany
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Interests: reactive sulfur species in biology; redox active secondary metabolites and their potential uses in agricultural medicine; redox modulators (either natural or synthetic) as potential drugs and green pesticides; synthetic chemistry of sulfur, selenium, and tellurium agents; solubilization of redox active particles using nanotechnology; oligomeric natural products capable of controling protein function and enzyme activity
Redox active secondary metabolites from diverse plants, mushrooms, and microorganisms have recently attracted considerable interest because of their abundance in nature and often pronounced biological activity. Redox active organic sulfur compounds (OSCs) from plants like garlic, onions and mustard frequently exhibit distinct cytotoxic and antimicrobial activities. In contrast, polyphenols, such flavonoids and resveratrol, show antioxidant activities, are able to trigger various cellular signaling cascades, and also influence epigenomic processes.
Not surprisingly, many of these natural products may be useful in medicine and agriculture. In medicine, chemo-preventive and antioxidant activities are of particular interest; these qualities are especially useful for the (pre-emptive) treatment of an aging population. Because some of these natural products (and related compounds) also possess pronounced cytotoxic and antimicrobial properties, these products may potentially also be applied as antibiotics or fungicides. In agricultural research, the development of ecologically friendly plant protective agents, based on these redox active secondary metabolites, holds equal promise.
Various techniques have recently been developed and applied to understand the underlying biochemical processes responsible for these substances’ biological activities. These studies have revealed an often complex interplay of different intracellular redox events. These events result in the activation of a range of cellular signaling and response pathways. Such events may include, for instance, the activation of antioxidant pathways, the (mostly reversible) modification of key cysteine residues in proteins and enzymes of the cellular thiolstat, the up-regulation of reactive oxygen species, and epigenomic changes to the histones.
This Special Issue will therefore consider the latest developments in natural products research, with a particular focus on redox active secondary metabolites. The issue will take an interdisciplinary point of view and include the isolation and characterization of such compounds, the synthesis of artificial derivatives, and the respective biological activity observed for such products. To complete the emerging picture of redox active metabolites, the issue will also reflect on underlying cellular mechanisms and possible practical applications.
Prof. Dr. Claus Jacob
Manuscript Submission Information
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- green pesticides
- infectious diseases
- inflammatory diseases
- reactive sulfur species
- redox modulators
- secondary metabolites