Special Issue "Redox Active Natural Products and Their Interaction with Cellular Signalling Pathways"


A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Metabolites".

Deadline for manuscript submissions: closed (31 May 2014)

Special Issue Editor

Guest Editor
Prof. Dr. Claus Jacob
Division of Bioorganic Chemistry, School of Pharmacy, University of Saarland, Campus, 66123 Saarbrücken, Germany
Website: http://www.uni-saarland.de/campus/fakultaeten/professuren/naturwissenschaftlich-technische-fakultaet-iii/pharmazie/professuren-fr-82-pharmazie/claus-jacob/mitarbeiter/professor.html
E-Mail: c.jacob@mx.uni-saarland.de
Interests: reactive sulfur species in biology; redox active secondary metabolites and their potential uses in agricultural medicine; redox modulators (either natural or synthetic) as potential drugs and green pesticides; synthetic chemistry of sulfur, selenium, and tellurium agents; solubilization of redox active particles using nanotechnology; oligomeric natural products capable of controling protein function and enzyme activity

Special Issue Information

Dear Colleagues,

Redox active secondary metabolites from diverse plants, mushrooms, and microorganisms have recently attracted considerable interest because of their abundance in nature and often pronounced biological activity. Redox active organic sulfur compounds (OSCs) from plants like garlic, onions and mustard frequently exhibit distinct cytotoxic and antimicrobial activities. In contrast, polyphenols, such flavonoids and resveratrol, show antioxidant activities, are able to trigger various cellular signaling cascades, and also influence epigenomic processes.

Not surprisingly, many of these natural products may be useful in medicine and agriculture. In medicine, chemo-preventive and antioxidant activities are of particular interest; these qualities are especially useful for the (pre-emptive) treatment of an aging population. Because some of these natural products (and related compounds) also possess pronounced cytotoxic and antimicrobial properties, these products may potentially also be applied as antibiotics or fungicides. In agricultural research, the development of ecologically friendly plant protective agents, based on these redox active secondary metabolites, holds equal promise.

Various techniques have recently been developed and applied to understand the underlying biochemical processes responsible for these substances’ biological activities. These studies have revealed an often complex interplay of different intracellular redox events. These events result in the activation of a range of cellular signaling and response pathways. Such events may include, for instance, the activation of antioxidant pathways, the (mostly reversible) modification of key cysteine residues in proteins and enzymes of the cellular thiolstat, the up-regulation of reactive oxygen species, and epigenomic changes to the histones.

This Special Issue will therefore consider the latest developments in natural products research, with a particular focus on redox active secondary metabolites. The issue will take an interdisciplinary point of view and include the isolation and characterization of such compounds, the synthesis of artificial derivatives, and the respective biological activity observed for such products. To complete the emerging picture of redox active metabolites, the issue will also reflect on underlying cellular mechanisms and possible practical applications.

Prof. Dr. Claus Jacob
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).


  • cancer
  • green pesticides
  • infectious diseases
  • inflammatory diseases
  • macrophages
  • reactive sulfur species
  • redox modulators
  • secondary metabolites
  • selenium
  • tellurium
  • thiolstat

Published Papers (7 papers)

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Displaying article 1-7
p. 14496-14527
by , , , , , , , , ,  and
Molecules 2014, 19(9), 14496-14527; doi:10.3390/molecules190914496
Received: 28 May 2014; in revised form: 2 September 2014 / Accepted: 3 September 2014 / Published: 12 September 2014
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p. 12727-12759
by ,  and
Molecules 2014, 19(8), 12727-12759; doi:10.3390/molecules190812727
Received: 18 July 2014; in revised form: 6 August 2014 / Accepted: 12 August 2014 / Published: 20 August 2014
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p. 12591-12618
by , , ,  and
Molecules 2014, 19(8), 12591-12618; doi:10.3390/molecules190812591
Received: 23 June 2014; in revised form: 24 July 2014 / Accepted: 28 July 2014 / Published: 19 August 2014
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p. 12258-12279
by , , , , , , , , ,  and
Molecules 2014, 19(8), 12258-12279; doi:10.3390/molecules190812258
Received: 13 June 2014; in revised form: 22 July 2014 / Accepted: 24 July 2014 / Published: 13 August 2014
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p. 10818-10831
by , , ,  and
Molecules 2014, 19(8), 10818-10831; doi:10.3390/molecules190810818
Received: 21 May 2014; in revised form: 10 July 2014 / Accepted: 15 July 2014 / Published: 24 July 2014
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p. 10011-10032
by , , , ,  and
Molecules 2014, 19(7), 10011-10032; doi:10.3390/molecules190710011
Received: 3 June 2014; in revised form: 20 June 2014 / Accepted: 25 June 2014 / Published: 10 July 2014
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p. 8317-8333
by , , ,  and
Molecules 2014, 19(6), 8317-8333; doi:10.3390/molecules19068317
Received: 12 May 2014; in revised form: 8 June 2014 / Accepted: 11 June 2014 / Published: 19 June 2014
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Last update: 10 July 2014

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