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Molecules 2014, 19(8), 12727-12759; doi:10.3390/molecules190812727

Effect of Redox Modulating NRF2 Activators on Chronic Kidney Disease

1
College of Pharmacy, The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Korea
2
Daewon Foreign Language High School, Kwangjin-gu, Seoul 143-713, Korea
*
Author to whom correspondence should be addressed.
Received: 18 July 2014 / Revised: 6 August 2014 / Accepted: 12 August 2014 / Published: 20 August 2014
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Abstract

Chronic kidney disease (CKD) is featured by a progressive decline of kidney function and is mainly caused by chronic diseases such as diabetes mellitus and hypertension. CKD is a complex disease due to cardiovascular complications and high morbidity; however, there is no single treatment to improve kidney function in CKD patients. Since biological markers representing oxidative stress are significantly elevated in CKD patients, oxidative stress is receiving attention as a contributing factor to CKD pathology. Nuclear factor erythroid-2 related factor 2 (NRF2) is a predominant transcription factor that regulates the expression of a wide array of genes encoding antioxidant proteins, thiol molecules and their generating enzymes, detoxifying enzymes, and stress response proteins, all of which can counteract inflammatory and oxidative damages. There is considerable experimental evidence suggesting that NRF2 signaling plays a protective role in renal injuries that are caused by various pathologic conditions. In addition, impaired NRF2 activity and consequent target gene repression have been observed in CKD animals. Therefore, a pharmacological intervention activating NRF2 signaling can be beneficial in protecting against kidney dysfunction in CKD. This review article provides an overview of the role of NRF2 in experimental CKD models and describes current findings on the renoprotective effects of naturally occurring NRF2 activators, including sulforaphane, resveratrol, curcumin, and cinnamic aldehyde. These experimental results, coupled with recent clinical experiences with a synthetic triterpenoid, bardoxolone methyl, have brought a light of hope for ameliorating CKD progression by preventing oxidative stress and maintaining cellular redox homeostasis. View Full-Text
Keywords: chronic kidney disease; oxidative stress; inflammation; NRF2, sulforaphane; resveratrol; curcumin; cinnamic aldehyde chronic kidney disease; oxidative stress; inflammation; NRF2, sulforaphane; resveratrol; curcumin; cinnamic aldehyde
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Choi, B.-H.; Kang, K.-S.; Kwak, M.-K. Effect of Redox Modulating NRF2 Activators on Chronic Kidney Disease. Molecules 2014, 19, 12727-12759.

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