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Special Issue "Frontiers in Metal-Catalysed Cross-Coupling Reactions for the Synthesis and Functionalisation of Heterocycles"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: 31 May 2018

Special Issue Editors

Guest Editor
Prof. Dr. Artur M. S. Silva

QOPNA & Department of Chemistry, University of Aveiro, Portugal
Website | E-Mail
Interests: organic synthesis; organocatalysis, transition-metal catalysis; oxygen and nitrogen heterocyclic compounds; chemistry of natural products; green chemistry; microwave-assisted organic synthesis; ohmic heating-assisted organic synthesis
Guest Editor
Dr. Maria Manuel Marques

Chemistry Department, Faculty of Science and Technology - UNL, Caparica, Portugal
Website | E-Mail
Interests: organic synthesis; palladium-catalysed reactions; heterocyclic compounds; sustainable synthetic methods; medicinal chemistry; development of synthetic methods; carbohydrate chemistry

Special Issue Information

Dear Colleagues,

Transition metal-catalyzed cross-coupling reactions are of paramount importance in organic synthesis. Over the past 30 years, metal-catalyzed C−X (X = C, N, O, S, etc.) bond formation reactions received considerable attention due to their convenience and efficiency. These methods have profoundly changed the protocols for the construction of natural products, building blocks for supramolecular chemistry and self-assembly, pharmaceuticals, agrochemicals, and advanced materials on both laboratory and industrial scales.

Nowadays, transition metal-catalysed cross-coupling reactions constitute an important tool for the synthesis and functionalization of several types of heterocyclic compounds, but the field is still wide-open for innovation and will continue to advance as even more versatile transformations are developed. For instance, multicomponent reactions have been used for the synthesis of heterocycles and many strategies have been developed for the construction of highly functionalized heterocycles, but there are also works focused on the direct functionalization of heteroaromatic compounds.

The present Special Issue intends to highlight updated contributions in the construction and functionalisation of heterocyclic compounds and derivatives involving transition metal-catalyzed cross-coupling reactions as the key step. Reviews articles by experts in the field will also be welcome.

Prof. Dr. Artur M. S. Silva
Dr. Maria Manuel Marques
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Metal-catalysis
  • Cross-coupling reactions
  • Transmetallation
  • Mechanisms of cross-coupling reactions
  • Reductive elimination
  • Oxidative addition
  • Heterocycles
  • Synthesis of heterocycles
  • Functionalization of heterocycles
  • Microwave-assisted reactions

Published Papers

This special issue is now open for submission.
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