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Molecules 2018, 23(6), 1449; https://doi.org/10.3390/molecules23061449

Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents

Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI Paris, CNRS, PSL Research University 10, rue Vauquelin 75231 Paris CEDEX 05, France
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Received: 16 May 2018 / Revised: 6 June 2018 / Accepted: 7 June 2018 / Published: 14 June 2018
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Abstract

(Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these attractive scaffolds. An overview of our work concerning the cobalt-catalyzed arylation of iodo-substituted cyclic amines is presented. View Full-Text
Keywords: N-heterocycle; piperidine; pyrrolidine; azetidine; cross-coupling; cobalt; Grignard reagent N-heterocycle; piperidine; pyrrolidine; azetidine; cross-coupling; cobalt; Grignard reagent
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Barré, B.; Gonnard, L.; Guérinot, A.; Cossy, J. Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents. Molecules 2018, 23, 1449.

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