Special Issue "Free Radicals and Radical Ions"


A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: closed (31 August 2014)

Special Issue Editors

Guest Editor
Prof. Dr. John C. Walton
School of Chemistry, EaStChem, University of St. Andrews, St. Andrews, Fife KY16 9ST, UK
Website: http://www.st-andrews.ac.uk/chemistry/contact/academic/#jcw
E-Mail: jcw@st-andrews.ac.uk
Interests: organic synthetic methods; free-radical chemistry; EPR spectroscopy

Guest Editor
Prof. Dr. Ffrancon Williams
Department of Chemistry, University of Tennessee, Knoxville, Tennessee, USA
Website: https://www.chem.utk.edu/faculty/fwilliam
E-Mail: williams@ion.chem.utk.edu
Interests: matrix ESR spectroscopy of radical anions and radical cations; quantum tunneling in hydrogen-atom transfer reactions; vibronic coupling in molecular ions; radical cation rearrangements; radiation-induced cationic polymerization

Special Issue Information

Dear Colleagues,

Reactive free radicals and radical ions are some of the most important classes of reactive intermediates in the chemical, polymer, and biological sciences. Also, stable varieties of free radicals are hugely important in conducting and magnetic materials. New radical-based reagents, including those derived from peroxides, boron-based compounds, oxime derivatives, epoxides, metal hydrides, and others, are at the forefront of advances in synthetic chemistry. Novel radical-mediated procedures, including cyclizations, cascades, radical to nucleophile couplings and cyclizations, and radical-regulated catalytic systems with one or two electron donors, are all equally exciting. They all have contributed to a notable flowering of innovative synthetic methodologies.

The involvement of fresh radical-ordered procedures has deeply penetrated polymer science. Furthermore, novel radical-containing magnetic materials and conductors are expanding horizons in materials science. Although relatively unexplored, in comparison with their neutral molecule counterparts, radical ions participate in a broad swath of important processes by virtue of rapid electron-transfer reactions, which can be induced by both chemical catalysis and either photo- or radiation-chemical means. The use of radical ions in organic synthesis continues to develop with the radical-cation modification of the Cope reaction and similar rearrangements, as well as by their participation in the well-established Hofmann-Löffler, Würtz, and Birch reactions. Biochemical applications feature the interplay of simple oxygen–containing species, such as the oxygen radical anion O2─ and its protonated form, HO2. Also, the key role of radical ions in the important emerging technologies of alternative energy sources is illustrated by their involvement in the complementary fields of photovoltaics and light-emitting diodes.

Research articles covering all areas of free radical and radical ion chemistry, such as synthetic advances and applications, mechanistic insights, spectroscopic, structural, computational, and kinetic studies, as well as biochemical and electrochemical applications, are welcomed for inclusion in this Special Issue of Molecules.

Prof. Dr. John C. Walton
Prof. Dr. T. Ffrancon Williams
Guest Editors


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).


  • reactive intermediates
  • synthetic methods
  • redox (electron transfer) processes
  • radical and radical cation cyclizations
  • organic and biochemical mechanisms
  • electron donors
  • characterization by electron spin and paramagnetic properties

Published Papers (3 papers)

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Displaying article 1-3
p. 15026-15041
by , , ,  and
Molecules 2014, 19(9), 15026-15041; doi:10.3390/molecules190915026
Received: 28 July 2014; in revised form: 9 September 2014 / Accepted: 12 September 2014 / Published: 18 September 2014
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(This article belongs to the Special Issue Free Radicals and Radical Ions)
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p. 13486-13497
by , ,  and
Molecules 2014, 19(9), 13486-13497; doi:10.3390/molecules190913486
Received: 24 July 2014; in revised form: 22 August 2014 / Accepted: 25 August 2014 / Published: 1 September 2014
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(This article belongs to the Special Issue Free Radicals and Radical Ions)
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p. 11999-12010
by  and
Molecules 2014, 19(8), 11999-12010; doi:10.3390/molecules190811999
Received: 24 June 2014; in revised form: 29 July 2014 / Accepted: 1 August 2014 / Published: 11 August 2014
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Last update: 18 July 2014

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