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Molecules 2014, 19(11), 19137-19151; doi:10.3390/molecules191119137

Synthetic Applications of Intramolecular Thiol-Ene “Click” Reactions

Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland
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Received: 17 October 2014 / Revised: 13 November 2014 / Accepted: 14 November 2014 / Published: 19 November 2014
(This article belongs to the Special Issue Free Radicals and Radical Ions)
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Abstract

The intermolecular thiol-ene reaction is emerging as a highly efficient; free-radical mediated “click” process with diverse applications in biofunctionalisation and materials science. The related intramolecular thiol-ene reactions offer significant potential for the preparation of a wide range of sulphur containing heterocycles including synthetic therapeutics such as cyclic peptides and thiosugars. Herein, we review recent advances in intramolecular thiyl-radical mediated reactions and their applications for synthetic and medicinal chemistry. View Full-Text
Keywords: free radical; organic synthesis; carbohydrate; peptide free radical; organic synthesis; carbohydrate; peptide
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MDPI and ACS Style

Scanlan, E.M.; Corcé, V.; Malone, A. Synthetic Applications of Intramolecular Thiol-Ene “Click” Reactions. Molecules 2014, 19, 19137-19151.

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