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Molecules 2016, 21(7), 951; doi:10.3390/molecules21070951

Recent Advances in Substrate-Controlled Asymmetric Induction Derived from Chiral Pool α-Amino Acids for Natural Product Synthesis

1
College of Pharmacy, Research Institute of Pharmaceutical Science, Gyeongsang National University, Jinju daero, Jinju 52828, Korea
2
College of Pharmacy, Pusan National University, Busan 46241, Korea
3
College of Pharmacy, Dankook University, Cheonan 31116, Korea
*
Author to whom correspondence should be addressed.
Academic Editors: Carlo Siciliano and Constantinos M. Athanassopoulos
Received: 15 June 2016 / Revised: 7 July 2016 / Accepted: 18 July 2016 / Published: 21 July 2016
(This article belongs to the Special Issue Synthesis of Bioactive Compounds from the Chiral Pool)
View Full-Text   |   Download PDF [3806 KB, uploaded 21 July 2016]   |  

Abstract

Chiral pool α-amino acids have been used as powerful tools for the total synthesis of structurally diverse natural products. Some common naturally occurring α-amino acids are readily available in both enantiomerically pure forms. The applications of the chiral pool in asymmetric synthesis can be categorized prudently as chiral sources, devices, and inducers. This review specifically examines recent advances in substrate-controlled asymmetric reactions induced by the chirality of α-amino acid templates in natural product synthesis research and related areas. View Full-Text
Keywords: chiral pool; α-amino acid; natural product; total synthesis; asymmetric induction chiral pool; α-amino acid; natural product; total synthesis; asymmetric induction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Paek, S.-M.; Jeong, M.; Jo, J.; Heo, Y.M.; Han, Y.T.; Yun, H. Recent Advances in Substrate-Controlled Asymmetric Induction Derived from Chiral Pool α-Amino Acids for Natural Product Synthesis. Molecules 2016, 21, 951.

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