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Molecules 2016, 21(7), 925; doi:10.3390/molecules21070925

A New Class of Glucosyl Thioureas: Synthesis and Larvicidal Activities

1
Department of Medicinal Chemistry, School of Pharmacy, The Fourth Military Medical University, Changle West Road 169, Xi’an 710032, China
2
Research & Department Center of Biorational Pesticides, Northwest Agriculture & Forestry University, No. 3 Taicheng Road, Yangling 712100, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Carlo Siciliano and Roman Dembinski
Received: 13 April 2016 / Revised: 4 July 2016 / Accepted: 12 July 2016 / Published: 16 July 2016
(This article belongs to the Special Issue Synthesis of Bioactive Compounds from the Chiral Pool)
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Abstract

A novel series of glucosyl thioureas were synthesized in good overall yields (up to 37% over four steps) from d-glucose and primary amines, and their larvicidal activities toward Mythimna separata Walker were also investigated. This new class of glucosyl thioureas demonstrated low to moderate growth inhibition activity of Mythiman separata Walker, with a growth inhibitory rate of up to 47.5% at a concentration of 100.0 mg/L in acetone. View Full-Text
Keywords: glucosyl thiourea; chitin synthase inhibitor; anti-chitin structure; larvicidal activity; growth inhibitory rate glucosyl thiourea; chitin synthase inhibitor; anti-chitin structure; larvicidal activity; growth inhibitory rate
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Wang, P.-A.; Feng, J.-T.; Wang, X.-Z.; Li, M.-Q. A New Class of Glucosyl Thioureas: Synthesis and Larvicidal Activities. Molecules 2016, 21, 925.

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