Special Issue "G-Quadruplexes & i-Motif DNA"

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A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (31 August 2013)

Special Issue Editor

Guest Editor
Prof. Dr. Edwin A. Lewis
Department of Chemistry, 1115 Hand Lab, Box 9573, Mississippi State, MS 39762, USA
Website: http://www.chemistry.msstate.edu/people/faculty/detail.php?faculty=lewis
E-Mail: ELewis@chemistry.msstate.edu
Phone: +1 662 325 3354
Fax: +1 662 325 1618
Interests: structure, stability, and drug binding properties of G-quadruplex and i-Motif DNA's; biological function of G-quadruplex and i-Motif forming sequences located in the regulatory regions of more than 40% of all human genes; drugability of G-quadruplex and i-Motif features found in the promoter regions of many oncogenes, e.g. c-MYC, Bcl-2, and K-ras; the use of thermodynamics for specific DNA-small molecule interactions in rational drug design

Special Issue Information

Dear Colleagues,

Guanine has long been known to self associate by π-π stacking or into G-tetrads stabilized by Hoogsteen H-bonds between N2 and N7, and N1 and O6 on adjacent guanines. Short G-rich DNA (or RNA) sequences can also form intermolecular G-quadruplexes containing from 1 to 4 DNA strands while longer G-rich sequences can fold back onto themselves forming intramolecular G-quadruplexes. It is now known that G-quadruplex forming sequences are found throughout the genome with more than 40% of all human genes having a potential G-quadruplex forming sequence located within 1 kb of the gene start site. Obviously, wherever there is a G-quadruplex forming sequence in one strand the complimentary strand contains a C-rich sequence capable of forming an i-motif. Even though G-quadruplexes have been studied for more than 20 years, the exact nature of their biological significance, other than in the single strand telomere overhang, is not well understood. It is commonly thought that G-quadruplexes and i-motif DNA must be important in gene regulation. For this reason, the G-quadruplex and i-motif structures represent attractive drug targets; small molecules that can stabilize these structures have been investigated as anti-cancer therapeutics. The stabilized higher order structures cannot bind to proteins required to form the transcriptionally active complex thereby down regulating the gene (or oncogene) having G-rich promoter sequences. Several proteins have been found that recognize quadruplex structure including loop bases and sequence. Other than their biological interest, the g-quadruplex and i-motif structures are gaining interest in the materials and nano-materials areas. G-quadruplex structure is known to be sensitive the stabilizing cation (e.g. Na+ vs. K+) while the i-motif structure is known to be sensitive to pH. These properties raise the possibility that sensors or switches could be fabricated using G-quadruplexes or i-motifs. The general focus of this special issue of Molecules will be to look at the structure, stability and ligand binding properties of G-quadruplexes and i-motifs, particularly from the standpoint of their biological activity or their materials properties.

Dr. Edwin A. Lewis
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).

Keywords

  • G-quadruplex
  • G-tetrad
  • i-motif
  • intercalative motif
  • drug discovery/design
  • ligand binding
  • biomedical
  • hoogsteen hydrogen bonding
  • telomere
  • gene regulation
  • oncogenes
  • materials
  • nano-materials
  • conformational switches
  • supramolecular
  • cancer

Published Papers (14 papers)

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Displaying article 1-14
p. 2286-2298
by  and
Molecules 2014, 19(2), 2286-2298; doi:10.3390/molecules19022286
Received: 29 September 2013; in revised form: 24 January 2014 / Accepted: 7 February 2014 / Published: 21 February 2014
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(This article belongs to the Special Issue G-Quadruplexes & i-Motif DNA)
p. 595-608
by  and
Molecules 2014, 19(1), 595-608; doi:10.3390/molecules19010595
Received: 6 November 2013; in revised form: 13 December 2013 / Accepted: 18 December 2013 / Published: 6 January 2014
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(This article belongs to the Special Issue G-Quadruplexes & i-Motif DNA)
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p. 15434-15447
by , ,  and
Molecules 2013, 18(12), 15434-15447; doi:10.3390/molecules181215434
Received: 7 November 2013; in revised form: 25 November 2013 / Accepted: 3 December 2013 / Published: 11 December 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (1752 KB)
(This article belongs to the Special Issue G-Quadruplexes & i-Motif DNA)
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p. 15019-15034
by , ,  and
Molecules 2013, 18(12), 15019-15034; doi:10.3390/molecules181215019
Received: 25 September 2013; in revised form: 25 November 2013 / Accepted: 26 November 2013 / Published: 5 December 2013
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(This article belongs to the Special Issue G-Quadruplexes & i-Motif DNA)
p. 14760-14779
by , , , ,  and
Molecules 2013, 18(12), 14760-14779; doi:10.3390/molecules181214760
Received: 9 September 2013; in revised form: 13 November 2013 / Accepted: 13 November 2013 / Published: 28 November 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (684 KB)
(This article belongs to the Special Issue G-Quadruplexes & i-Motif DNA)
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p. 14228-14240
by  and
Molecules 2013, 18(11), 14228-14240; doi:10.3390/molecules181114228
Received: 7 October 2013; in revised form: 4 November 2013 / Accepted: 8 November 2013 / Published: 18 November 2013
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(This article belongs to the Special Issue G-Quadruplexes & i-Motif DNA)
p. 13588-13607
by , , , , , , ,  and
Molecules 2013, 18(11), 13588-13607; doi:10.3390/molecules181113588
Received: 30 August 2013; in revised form: 26 October 2013 / Accepted: 29 October 2013 / Published: 4 November 2013
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(This article belongs to the Special Issue G-Quadruplexes & i-Motif DNA)
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p. 13446-13470
by , , , , , ,  and
Molecules 2013, 18(11), 13446-13470; doi:10.3390/molecules181113446
Received: 27 September 2013; in revised form: 21 October 2013 / Accepted: 23 October 2013 / Published: 30 October 2013
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(This article belongs to the Special Issue G-Quadruplexes & i-Motif DNA)
p. 13297-13319
by  and
Molecules 2013, 18(11), 13297-13319; doi:10.3390/molecules181113297
Received: 30 August 2013; in revised form: 5 October 2013 / Accepted: 24 October 2013 / Published: 29 October 2013
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(This article belongs to the Special Issue G-Quadruplexes & i-Motif DNA)
p. 12751-12767
by , ,  and
Molecules 2013, 18(10), 12751-12767; doi:10.3390/molecules181012751
Received: 16 August 2013; in revised form: 26 September 2013 / Accepted: 10 October 2013 / Published: 15 October 2013
Show/Hide Abstract | Cited by 5 | PDF Full-text (423 KB) | Supplementary Files
(This article belongs to the Special Issue G-Quadruplexes & i-Motif DNA)
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p. 12368-12395
by , ,  and
Molecules 2013, 18(10), 12368-12395; doi:10.3390/molecules181012368
Received: 14 August 2013; in revised form: 24 September 2013 / Accepted: 27 September 2013 / Published: 8 October 2013
Show/Hide Abstract | Cited by 6 | PDF Full-text (1219 KB)
(This article belongs to the Special Issue G-Quadruplexes & i-Motif DNA)
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p. 12051-12070
by , , ,  and
Molecules 2013, 18(10), 12051-12070; doi:10.3390/molecules181012051
Received: 4 September 2013; in revised form: 18 September 2013 / Accepted: 22 September 2013 / Published: 30 September 2013
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(This article belongs to the Special Issue G-Quadruplexes & i-Motif DNA)
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p. 11938-11963
by , , , , , ,  and
Molecules 2013, 18(10), 11938-11963; doi:10.3390/molecules181011938
Received: 22 August 2013; in revised form: 10 September 2013 / Accepted: 17 September 2013 / Published: 26 September 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (357 KB)
(This article belongs to the Special Issue G-Quadruplexes & i-Motif DNA)
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p. 11751-11767
by , ,  and
Molecules 2013, 18(10), 11751-11767; doi:10.3390/molecules181011751
Received: 9 August 2013; in revised form: 5 September 2013 / Accepted: 11 September 2013 / Published: 25 September 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (981 KB) | Supplementary Files
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Last update: 26 August 2014

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